1 The pharmacokinetics of mianserin hydrochloride have been determined in eight normal healthy volunteers, mean age 27, and 14 elderly patients, mean age 76. 2 Mianserin was administered to volunteers by intravenous infusion (0.011 mg/kg/min for 15 min) and, on another occasion, by mouth, in a single dose of 30 mg. Elderly patients received a single oral dose of 40-60 mg. 3 The terminal elimination half-life was significantly prolonged in the elderly. In young subjects it was 9.6 +/- 1.9 (s.d.) h. In the elderly it was 27 +/- 13.1 (s.d.) h. 4 Apparent oral clearance was significantly reduced in the elderly. In young subjects it was 87.1 +/- 32 (s.d.) h. In the elderly, it was 38.1 +/- 14.8 (s.d.) h. 5 These kinetic differences may have an important bearing on the sedative effects of mianserin.

中文翻译：

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米安色林的药代动力学。

1已在八名正常健康志愿者（平均年龄27岁）和14名老年患者（平均年龄76岁）中确定了盐酸米安色林的药代动力学。2通过静脉内输注（0.011 mg / kg / min持续15分钟）向志愿者施用米安色林。在另一场合，通过口服，单次服用30毫克。老年患者接受40-60 mg的单次口服剂量。3老年人的终末消除半衰期显着延长。在年轻受试者中，为9.6 +/- 1.9（sd）h。老年人为27 +/- 13.1（sd）h。4老年人的表观口腔间隙明显减少。在年轻受试者中为87.1 +/- 32（sd）h。在老年人中，为38.1 +/- 14.8（sd）h。5这些动力学差异可能对米安色林的镇静作用有重要影响。