Clinical isolates of Pseudomonas aeruginosa produce low molecular weight, hydrophobic substances which inhibit the growth of Staphylococcus aureus and other Gram-positive organisms. The active substances have been purified from a culture of P. aeruginosa and characterized as a mixture of 2-heptyl-4-hydroxyquinoline N-oxide and its homologues. The alkyl-hydroxyquinolines (derived through reduction of the N-oxide) were also produced by P. aeruginosa cultures but, in general, were less active against S. aureus. 2-Heptyl-4-hydroxyquinoline was identified in a sample of human bronchial secretions from a patient with cystic fibrosis who was heavily colonized with P. aeruginosa. Production of antibacterial alkyl-hydroxyquinoline N-oxides in human lung may explain the observation that the presence of P. aeruginosa in the sputum of patients with cystic fibrosis is correlated with the absence of S. aureus.

中文翻译：

---

2-庚基-4-羟基喹啉N-氧化物，一种由铜绿假单胞菌产生的抗葡萄球菌药。

临床分离的铜绿假单胞菌产生低分子量疏水物质，抑制金黄色葡萄球菌和其他革兰氏阳性生物的生长。活性物质已从铜绿假单胞菌的培养物中纯化，并表征为2-庚基-4-羟基喹啉N-氧化物及其同系物的混合物。铜绿假单胞菌培养物也产生烷基-羟基喹啉（通过还原N-氧化物而得），但通常对金黄色葡萄球菌的活性较低。在患有铜绿假单胞菌的囊性纤维化患者的人支气管分泌物样品中鉴定出了2-庚基-4-羟基喹啉。在人肺中产生抗菌烷基-羟基喹啉N-氧化物可能解释了P的存在的观察结果。