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The identification of 3,3', 5,5',-tetraiodothyroformic acid within the rat liver.
Biochemical Journal ( IF 4.4 ) Pub Date : 1974-10-01 , DOI: 10.1042/bj1430047 David B. Ramsden 1 , Alexander M. Lawson 2 , Philip J. Raw 1 , Raymond Hoffenberg 1
Biochemical Journal ( IF 4.4 ) Pub Date : 1974-10-01 , DOI: 10.1042/bj1430047 David B. Ramsden 1 , Alexander M. Lawson 2 , Philip J. Raw 1 , Raymond Hoffenberg 1
Affiliation
Homogenized rat livers were extracted with organic solvents and the extracts converted into more readily volatile derivatives (trimethylsilylmethyl esters and permethyl esters). Combined g.l.c.-mass-spectrometric analysis identified the presence of tetraiodothyroformate. It is postulated that mitochondrial beta-oxidation of tetraiodothyropyruvate results in the formation of this apparently undescribed metabolite.
中文翻译:
大鼠肝脏中3,3',5,5'-四碘甲甲酸的鉴定。
用有机溶剂提取均质的大鼠肝脏,并将提取物转化为易挥发的衍生物(三甲基甲硅烷基甲基酯和全甲酯)。组合的glc-质谱分析确定了四碘甲酸酯的存在。据推测,四碘甲状腺丙酮酸的线粒体β-氧化作用导致形成了这种表面上未描述的代谢物。
更新日期:2019-11-01
中文翻译:
大鼠肝脏中3,3',5,5'-四碘甲甲酸的鉴定。
用有机溶剂提取均质的大鼠肝脏,并将提取物转化为易挥发的衍生物(三甲基甲硅烷基甲基酯和全甲酯)。组合的glc-质谱分析确定了四碘甲酸酯的存在。据推测,四碘甲状腺丙酮酸的线粒体β-氧化作用导致形成了这种表面上未描述的代谢物。