Tetrabromobisphenol A (TBBPA) and cadmium chloride (CdCl2) are the typical representative pollutants of brominated flame retardants and heavy metals found in the air of e-waste recycling workshops. However, their metabolic kinetics through mixture inhalation is unknown. In the present study, 8-week old Institute of Cancer Research (ICR) male mice were whole-body exposed to TBBPA and CdCl2 mixtures by inhalation. Tissue samples were collected for TBBPA and cadmium (Cd) analysis at 2, 4, 6, and 8 weeks during exposure and at 4 and 8 weeks after the completion of the 8-week exposure period. TBBPA was mainly distributed to the lungs, liver, kidney, testis, and spleen, with a high amount accumulated in the brain, liver, and spleen. Cd was mainly distributed to the lungs, liver, and kidney, with a high amount accumulated in the liver, kidney, and testis and a low amount accumulated in brain and serum. Tissue burden of TBBPA and Cd in all organs increased in a dose- and time-dependent manner during the exposure period. However, 4 weeks after the completion of an 8-week exposure, TBBPA concentrations in the liver, testis, brain, and serum and Cd concentrations in the liver, testis, and kidney were higher than the corresponding tissue concentrations during the exposure period. The rapid accumulation of both TBBPA and Cd in the lungs after inhalation exposure indicated a high risk of the respiratory system diseases for workers in e-waste recycling workshops. In addition, the migration of both TBBPA and Cd from lungs to liver and testis may result in more complex toxic effects in vivo.

中文翻译：

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混合物吸入暴露中四溴双酚A和镉的组织分布。

四溴双酚A（TBBPA）和氯化镉（CdCl2）是在电子废物回收车间的空气中发现的溴化阻燃剂和重金属的典型代表污染物。但是，它们通过混合物吸入的代谢动力学尚不清楚。在本研究中，通过吸入使8周大的癌症研究所（ICR）雄性小鼠全身暴露于TBBPA和CdCl2混合物。在暴露期间的2、4、6和8周以及8周暴露期完成后的4和8周，收集组织样本用于TBBPA和镉（Cd）分析。TBBPA主要分布于肺，肝，肾，睾丸和脾脏，在脑，肝和脾脏中大量积累。镉主要分布在肺，肝和肾，在肝脏，肾脏，睾丸和少量的脑和血清中积累。在暴露期间，所有器官中的TBBPA和Cd的组织负荷以剂量和时间依赖性方式增加。但是，在完成8周的暴露后4周，肝脏，睾丸，脑，肝脏，睾丸和肾脏中的TBBPA浓度以及血清Cd浓度高于暴露期间相应的组织浓度。吸入暴露后，TBBPA和Cd迅速在肺中积累，这表明电子废物回收车间的工人患呼吸系统疾病的风险很高。此外，TBBPA和Cd从肺向肝脏和睾丸的迁移可能导致体内更复杂的毒性作用。在暴露期间，所有器官中的TBBPA和Cd的组织负荷以剂量和时间依赖性方式增加。但是，在完成8周的暴露后4周，肝脏，睾丸，脑，肝脏，睾丸和肾脏中的TBBPA浓度以及血清Cd浓度高于暴露期间相应的组织浓度。吸入暴露后，TBBPA和Cd迅速在肺中积累，这表明电子废物回收车间的工人患呼吸系统疾病的风险很高。另外，TBBPA和Cd从肺向肝脏和睾丸的迁移可能导致体内更复杂的毒性作用。在暴露期间，所有器官中的TBBPA和Cd的组织负荷以剂量和时间依赖性方式增加。但是，在完成8周的暴露后4周，肝脏，睾丸，脑，肝脏，睾丸和肾脏中的TBBPA浓度以及血清Cd浓度高于暴露期间相应的组织浓度。吸入暴露后，TBBPA和Cd迅速在肺中积累，这表明电子废物回收车间的工人患呼吸系统疾病的风险很高。此外，TBBPA和Cd从肺向肝脏和睾丸的迁移可能导致体内更复杂的毒性作用。在暴露期间，大脑，肝脏，睾丸和肾脏中的血清和Cd浓度高于相应的组织浓度。吸入暴露后，TBBPA和Cd迅速在肺中积累，这表明电子废物回收车间的工人患呼吸系统疾病的风险很高。此外，TBBPA和Cd从肺向肝脏和睾丸的迁移可能导致体内更复杂的毒性作用。在暴露期间，大脑，肝脏，睾丸和肾脏中的血清和Cd浓度高于相应的组织浓度。吸入暴露后，TBBPA和Cd迅速在肺中积累，这表明电子废物回收车间的工人患呼吸系统疾病的风险很高。此外，TBBPA和Cd从肺向肝脏和睾丸的迁移可能导致体内更复杂的毒性作用。