Tropanes are an important class of alkaloid natural products that are found in plants all over the world. These compounds can exhibit significant biological activity and are among the oldest known medicines. In the early 19th century, tropanes were isolated, characterized, and synthesized by notable chemical researchers. Their significant biological activities have inspired tremendous research efforts toward their synthesis and the elucidation of their pharmacological activity both in academia and in industry. In this chapter, which addresses the developments in this field since 1994, the focus is on the synthesis of these compounds, and several examples of sophisticated synthetic protocols involving both asymmetric and catalytic approaches are described. In addition, the structures of more than 100 new alkaloids are included as well as the applications and pharmacological properties of some tropane alkaloids.

中文翻译：

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樟脑生物碱的化学合成及应用。

Tropanes是一类重要的生物碱天然产物，可在世界各地的植物中找到。这些化合物可表现出显着的生物学活性，并且是最古老的已知药物之一。在19世纪初期，著名的化学研究人员分离，表征并合成了托烷。它们的重要生物学活性激发了人们对其合成以及在学术界和工业界阐明其药理活性的巨大研究努力。本章论述了自1994年以来该领域的发展，重点是这些化合物的合成，并描述了涉及不对称和催化方法的复杂合成方案的几个示例。此外，