In this study, the total alkaloids of Huangteng were given to the rats by the methods of intragastric administration and tail vein. After the concentration changes of palmatine and jatrorrhizine in the plasma of rats were determined by RP-HPLC, pharmacokinetic parameters and oral bioavailability were calculated by 3P97 software. After the rats were pre-treated with total alkaloid 60 mg•kg⁻¹ by the methods of intragastric administration and tail vein, the main pharmacokinetic parameters were determined as follows： in the intragastric administration group, the Cmax of palmatine and jatrorrhizine were (0.91±0.06), (0.70±0.08) mg•L⁻¹; tmax of palmatine and jatrorrhizine were (35.24±0.83), (47.76±1.24) min; t1/2 of palmatine and jatrorrhizine were (187.03±1.53), (105.64±16.99) min, AUC of palmatine and jatrorrhizine were (280.30±18.69), (144.36±1.06) mg•min•L⁻¹; in the intravenous injection group, the t1/2 of palmatine and jatrorrhizine were (172.18±12.38), (147.26±1.82) min; AUC of palmatine and jatrorrhizine were (2 553.14±214.91), (328.83±10.81) mg•min•L⁻¹. The oral bioavailability of palmatine was 10.98% and jatrorrhizine was 43.90%.

中文翻译：

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黄藤中巴马汀和麻疯树碱的药代动力学和口服生物利用度

本研究采用胃内给药和尾静脉给药的方法，将黄藤总生物碱给予大鼠。用RP-HPLC法测定大鼠血浆中棕榈碱和麻疯子碱的浓度变化后，用3P97软件计算药代动力学参数和口服生物利用度。大鼠经胃内给药和尾静脉给药总生物碱60 mg•kg ^ 1预处理后，主要药代动力学参数确定如下：胃内给药组中，帕马汀和麻疯子碱的Cmax为（0.91 ±0.06），（0.70±0.08）mg•L⁻¹；Palmatine和Jatrorrhizine的tmax为（35.24±0.83），（47.76±1.24）min; Palmatine和Jatrorrhizine的t1 / 2为（187.03±1.53），（105.64±16.99）min，Palmatine和Jatrorrhizine的AUC为（280.30±18.69），（144.36±1）。06）mg•min•L⁻¹; 静脉注射组中，帕马汀和麻疯子碱的t1 / 2分别为（172.18±12.38），（147.26±1.82）min。Palmatine和Jatrorrhizine的AUC为（2553.14±214.91），（328.83±10.81）mg•min•L -1。巴马汀的口服生物利用度为10.98％，麻风树碱为43.90％。