Cuiaba 和 Charleville 病毒的基因组特征：虫媒病毒（弹状病毒科，Sripuvirus 属）感染爬行动物和两栖动物。,Virus Genes

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Cuiaba 和 Charleville 病毒的基因组特征：虫媒病毒（弹状病毒科，Sripuvirus 属）感染爬行动物和两栖动物。
Virus Genes ( IF 1.9 ) Pub Date : 2018-12-03 , DOI: 10.1007/s11262-018-1620-x
Nikos Vasilakis _{1,

2,

3} , Robert B Tesh _{1,

2,

3} , Steven G Widen ₄ , Divya Mirchandani ₅ , Peter J Walker ₆

Affiliation

弹状病毒科中的病毒在生态上非常多样化，可感染哺乳动物、鸟类、爬行动物、鱼类、植物和各种其他陆生和水生无脊椎动物。斯里普病毒属目前包括五种病毒，它们似乎在涉及爬行动物和白蛉的传播周期中循环。在这里，我们报告了从巴西收集的两栖动物 (Bufo marinus) 中分离的 Cuiaba 病毒 (CUIV) 和从白蛉 (Phlebotomus sp.) 和蜥蜴 (Gehyra australis) 中分离的 Charleville 病毒 (CHVV) 的完整编码序列分析。），在澳大利亚收集。CUIV 和 CHVV 在系统发育上与从完整 L 蛋白 (RdRp) 序列生成的最大似然树中的 sripuviruses 聚类。它们还与 sripuviruses 在基因组组织方面具有独特的特征，包括在基质蛋白 (M) 基因和糖蛋白 (G) 基因之间的额外基因 (U1)，以及在 G ORF 起始处附近编码预测跨膜蛋白的替代长开放阅读框。鉴于它们的系统发育关系、相似的基因组组织和相似的生态特征，我们建议将 CUIV 和 CHVV 指定为 Sripuvirus 属的新成员。

"点击查看英文标题和摘要"

Genomic characterisation of Cuiaba and Charleville viruses: arboviruses (family Rhabdoviridae, genus Sripuvirus) infecting reptiles and amphibians.

Viruses in the family Rhabdoviridae are ecologically very diverse, infecting mammals, birds, reptiles, fish, plants and a wide range of other terrestrial and aquatic invertebrates. The genus Sripuvirus currently comprises five viruses that appear to circulate in transmission cycles involving reptiles and sandflies. Here, we report an analysis of the complete coding sequences of Cuiaba virus (CUIV), isolated from an amphibian (Bufo marinus) collected in Brazil, and Charleville virus (CHVV), isolated from sandflies (Phlebotomus sp.) and lizards (Gehyra australis), collected in Australia. CUIV and CHVV cluster phylogenetically with the sripuviruses in maximum likelihood trees generated from complete L protein (RdRp) sequences. They also share with sripuviruses unique features in genome organisation, including an additional gene (U1) between the matrix protein (M) gene and glycoprotein (G) gene, and an alternative long open reading frame near the start of the G ORF that encodes a predicted transmembrane protein. In view of their phylogenetic relationships, similar genome organisations and similar ecological characteristics, we propose the assignment of CUIV and CHVV as novel members of the genus Sripuvirus.

更新日期：2019-11-01

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