海马CA3激活减轻了由VTA电刺激引起的大鼠前额叶皮层的fMRI-BOLD反应。,PLOS ONE

当前位置： X-MOL 学术 › PLOS ONE › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

海马CA3激活减轻了由VTA电刺激引起的大鼠前额叶皮层的fMRI-BOLD反应。
PLOS ONE ( IF 2.9 ) Pub Date : 2017-02-28 , DOI: 10.1371/journal.pone.0172926
Thomas Scherf ₁ , Frank Angenstein _{1,

2}

Affiliation

功能磁共振成像（fMRI）用于鉴定通过腹侧被盖区（VTA）或海马CA3区的电刺激而激活的全脑网络。刺激这些区域之一会在常见结构（例如隔垫和左右海马区）中以及在独特结构（例如内侧前额叶皮层区域/前扣带区域（mPFC / ACC）和纹状体）中引起明显的BOLD反应，仅在VTA刺激期间被激活。与单独的VTA刺激相比，同时刺激两个结构不会在mPFC / ACC中产生加性BOLD反应，但会显着降低BOLD反应。这种减少是由于海马CA3区的共同刺激引起的，这本身不足以修改mPFC / ACC中的BOLD信号强度。在此实验条件下，在直接电刺激VTA投射神经元的驱动下，VTA和mPFC / ACC之间的功能连通性是神经生理相互作用的原因，一旦同时发生海马投射，相关BOLD时间序列的功能连通性就会被掩盖共激活的mPFC神经元。该结果警告不要误解fMRI数据集中功能连接的缺失，因为不相关的网络活动可能会掩盖现有的强大神经生理学相互作用。在直接电刺激VTA投射神经元的过程中，一旦海马投射同时激活了mPFC神经元，相关BOLD时间序列的功能连接就被掩盖了。该结果警告不要误解fMRI数据集中功能连接的缺失，因为不相关的网络活动可能会掩盖现有的强大神经生理学相互作用。在直接电刺激VTA投射神经元的过程中，一旦海马投射同时激活了mPFC神经元，相关BOLD时间序列的功能连接就被掩盖了。该结果警告不要误解fMRI数据集中功能连接的缺失，因为不相关的网络活动可能会掩盖现有的强大神经生理学相互作用。

"点击查看英文标题和摘要"

Hippocampal CA3 activation alleviates fMRI-BOLD responses in the rat prefrontal cortex induced by electrical VTA stimulation.

Functional magnetic resonance imaging (fMRI) was used to identify brain- wide networks that are activated by electrical stimulation of either the ventral tegmental area (VTA) or hippocampal CA3 region. Stimulation of either one of these regions caused significant BOLD responses in common structures, such as the septum and left and right hippocampus, but also in unique structures, such as the medial prefrontal cortex region/anterior cingulum region (mPFC/ACC) and striatum, which were only activated during VTA stimulation. Concurrent stimulations of the two structures resulted in no additive BOLD responses but significantly reduced BOLD responses in the mPFC/ACC when compared with sole VTA stimulation. This reduction is caused by costimulation of the hippocampal CA3 region, which was itself not sufficient to modify BOLD signal intensities in the mPFC/ACC. Under this experimental condition, functional connectivity between VTA and mPFC/ACC in terms of neurophysiological interactions was causative, driven by direct electrical stimulation of VTA projecting neurons, the resulting functional connectivity in terms of correlated BOLD time series becoming masked as soon as hippocampal projections concurrently coactivated mPFC neurons. This result warns against misinterpretation of the absence of functional connectivity in fMRI data sets, because strong existing neurophysiological interactions can be obscured by unrelated network activities.

更新日期：2019-11-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南