Mangiferin (1,3,6,7‑tetrahydroxyxanthone‑C2‑β‑D‑glucoside) is a bioactive ingredient predominantly isolated from the mango tree, with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, cardioprotective, anti‑hyperuricemic, neuroprotective, antioxidant, anti‑inflammatory, antipyretic, analgesic, antibacterial, antiviral and immunomodulatory effects. Therefore, it possesses several health‑endorsing properties and is a promising candidate for further research and development. However, low solubility, mucosal permeability and bioavailability restrict the development of mangiferin as a clinical therapeutic, and chemical and physical modification is required to expand its application. This review comprehensively analyzed and collectively summarized the primary pharmacological actions of mangiferin that have been demonstrated in the literature, to support the potential future development of mangiferin as a novel therapeutic drug.

中文翻译：

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芒果苷：一种针对多种疾病的有效治疗剂（综述）。

芒果苷（1,3,6,7-四羟基氧杂蒽酮-C2-β-D-葡萄糖苷）是一种主要从芒果树中分离出来的生物活性成分，具有强大的抗氧化活性和多因素药理作用，包括抗糖尿病、抗肿瘤、调节脂肪代谢、保护心脏、抗高尿酸、神经保护、抗氧化、抗炎、解热、镇痛、抗菌、抗病毒和免疫调节作用。因此，它具有多种有益于健康的特性，是进一步研究和开发的有希望的候选者。然而，低溶解度、黏膜渗透性和生物利用度限制了芒果苷作为临床治疗药物的发展，需要对其进行化学和物理修饰以扩大其应用。