Among the different techniques proposed for preparing cyclodextrin inclusion complex in the solid state, mechanochemical activation by grinding appears as a fast, highly efficient, convenient, versatile, sustainable, and eco-friendly solvent-free method. This review is intended to give a systematic overview of the currently available data in this field, highlighting both the advantages as well as the shortcomings of such an approach. The possible mechanisms involved in the inclusion complex formation in the solid state, by grinding, have been illustrated. For each type of applied milling device, the respective process variables have been examined and discussed, together with the characteristics of the obtained products, also in relation with the physicochemical characteristics of both the drug and cyclodextrin subjected to grinding. The critical process parameters were evidenced in order to provide a useful guide for a rational selection of the most suitable conditions for an efficient inclusion complex preparation by grinding, with the final purpose of promoting a wider use of this effective solvent-free cyclodextrin inclusion complex preparation method in the solid state.

中文翻译：

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研磨作为无溶剂绿色化学方法制备固态环糊精包合物。

在制备固态环糊精包合物的不同技术中，研磨机械化学活化是一种快速、高效、方便、通用、可持续和环境友好的无溶剂方法。本综述旨在系统地概述该领域当前可用的数据，强调这种方法的优点和缺点。已经阐明了通过研磨在固态下形成包合物的可能机制。对于每种类型的应用研磨装置，都检查和讨论了各自的工艺变量，以及所获得产品的特性，以及与经过研磨的药物和环糊精的物理化学特性的关系。论证了关键工艺参数，为合理选择高效研磨制备包合物的最适宜条件提供有益指导，最终目的是促进这种有效的无溶剂环糊精包合物制剂的更广泛应用。固态方法。