Optimized glycemic control prevents and slows the progression of long-term complications in patients with type 1 and type 2 diabetes. In healthy individuals, a decrease in plasma glucose below the physiological range triggers defensive counterregulatory responses that restore euglycemia. Many individuals with diabetes harbor defects in their defenses against hypoglycemia, making iatrogenic hypoglycemia the Achilles heel of glycemic control. This Profile in Progress focuses on the seminal contributions of Philip E. Cryer, MD, to our understanding of hypoglycemia and glucose counterregulation, particularly his discovery of the syndrome of hypoglycemia-associated autonomic failure (HAAF).

中文翻译：

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菲利普·E·克莱尔 (Philip E. Cryer) 医学博士：对理解低血糖和血糖反调节以及 HAAF（克莱尔综合征）的发现做出了重大贡献。


优化血糖控制可预防 1 型和 2 型糖尿病患者的长期并发症并减缓其进展。在健康个体中，血浆葡萄糖降低至生理范围以下会引发防御性反调节反应，从而恢复血糖正常。许多糖尿病患者在抵抗低血糖方面存在缺陷，使得医源性低血糖成为血糖控制的致命弱点。本简介重点关注医学博士 Philip E. Cryer 对我们理解低血糖和血糖反调节的开创性贡献，特别是他对低血糖相关自主神经衰竭 (HAAF) 综合征的发现。