Local venous pain caused by dacarbazine (DTIC) injection is due to its photodegradation product 5-diazoimidazole-4-carboxamide (Diazo-IC). The production of Diazo-IC can be decreased by protecting the drug from light. Furthermore, the production of Diazo-IC reportedly increases with time; however, there are no studies reporting the association between the injection preparation time and local venous pain caused by the DTIC injection. We evaluated the efficacy of the following: (1) method used to shorten the injection preparation time and (2) method used to change the diluting solution for DTIC. We found that shortening the injection preparation time tended to decrease the local venous pain expression due to DTIC, and Veen F decreased the production of Diazo-IC compared with the normal saline and 5% glucose solution. These results indicate that shortening the injection preparation time may be effective in preventing the local venous pain caused by the DTIC injection; moreover, using Veen F for DTIC may also reduce the pain.

中文翻译：

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达卡巴嗪预防局部静脉疼痛的考虑。

达卡巴嗪（DTIC）注射引起的局部静脉疼痛是由于其光降解产物5-重氮咪唑-4-羧酰胺（重氮-IC）引起的。保护药物避光可以减少重氮-IC的产生。此外，据报道重氮-IC的产量随着时间增加；但是，尚无研究报告注射准备时间与DTIC注射引起的局部静脉疼痛之间的相关性。我们评估了以下方法的功效：（1）用于缩短注射制备时间的方法和（2）用于更改DTIC稀释液的方法。我们发现，缩短注射准备时间往往会降低由于DTIC引起的局部静脉疼痛表达，并且与生理盐水和5％葡萄糖溶液相比，Veen F降低了重氮-IC的产生。这些结果表明，缩短注射准备时间可以有效地预防由DTIC注射引起的局部静脉疼痛。此外，将Veen F用于DTIC还可以减轻疼痛。