Wnt /β-catenin激活剂香草酸甲酯的局部应用可增加雄激素性脱发症女性的头发计数和头发质量指数。,Journal of Cosmetic Dermatology

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Wnt /β-catenin激活剂香草酸甲酯的局部应用可增加雄激素性脱发症女性的头发计数和头发质量指数。
Journal of Cosmetic Dermatology ( IF 2.3 ) Pub Date : 2016-04-29 , DOI: 10.1111/jocd.12225
Antonella Tosti ₁ , Martin N Zaiac ₂ , Agnese Canazza ₂ , Fabian Sanchis-Gomar ₃ , Helios Pareja-Galeano _{3,

4} , Rafael Alis _{5,

6} , Alejandro Lucia _{3,

4} , Enzo Emanuele ₇

Affiliation

背景技术WNT /β-连环蛋白途径的激活已经成为雄激素性脱发（AGA）中的潜在治疗靶标。香草酸甲酯（MV）-一种安全的植物来源成分-最近被证明可以激活WNT /β-catenin信号传导。目的进行了两个不同的子研究。首先，我们设计了一个为期6个月，不受控制的开放标签的临床研究，以调查局部应用MV是否会增加女性AGA中的头发数和头发质量指数（HMI）。其次，我们对MV对AGA妇女头皮活检中WNT10B mRNA表达的影响进行了分子研究。方法总共包括20名AGA（辛克莱等级1-2）的白人女性（年龄范围：25-57岁）。研究产品是无酒精配方，以喷雾形式提供，含有0.2％MV作为活性成分。结果在临床研究中，发现毛发计数和HMI在6个月时与基线相比分别增加了6％（P <0.01）和12％（P <0.001）。没有参与者因不良反应而中止治疗，患者总体满意度良好。在分子水平上，研究产品的局部应用导致颞头皮区域的WNT10B mRNA表达水平增加了32％（P <0.001）。结论我们的试验数据表明，局部MV可通过诱导头皮中WNT10B的表达来增加头发数量和HMI，这可能是女性AGA的一种新型治疗策略。整体患者满意度很高。在分子水平上，研究产品的局部应用导致颞头皮区域的WNT10B mRNA表达水平增加了32％（P <0.001）。结论我们的试验数据表明，局部MV可通过诱导头皮中WNT10B的表达来增加头发数量和HMI，这可能是女性AGA的一种新型治疗策略。整体患者满意度很高。在分子水平上，研究产品的局部应用导致颞头皮区域的WNT10B mRNA表达水平增加了32％（P <0.001）。结论我们的试验数据表明，局部MV可通过诱导头皮中WNT10B的表达来增加头发数量和HMI，这可能是女性AGA的一种新型治疗策略。

"点击查看英文标题和摘要"

Topical application of the Wnt/β-catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia.

BACKGROUND Activation of the WNT/β-catenin pathway has emerged as a potential therapeutic target in androgenetic alopecia (AGA). Methyl vanillate (MV) - a safe plant-derived ingredient - has been recently shown to activate the WNT/β-catenin signaling. Objectives Two distinct substudies were conducted. First, we designed a 6-month, uncontrolled, open-label clinical study to investigate whether topically applied MV may increase hair count and hair mass index (HMI) in female AGA. Second, we conducted a molecular study on the effect of MV on WNT10B mRNA expression in scalp biopsies of women with AGA. METHODS A total of 20 Caucasian women (age range: 25-57 years) with AGA (Sinclair grade 1-2) were included. The research product was an alcohol-free formulation supplied in the form of a spray containing 0.2% MV as the active ingredient. RESULTS In the clinical study, hair count and HMI were found to increase at 6 months by 6% (P < 0.01) and 12% (P < 0.001), respectively, compared with baseline. No participant discontinued treatment due to adverse effects, and the overall patient satisfaction was good. At the molecular level, the topical application of the research product resulted in a 32% increase in WNT10B mRNA expression levels in the temporal scalp area (P < 0.001). CONCLUSION Our pilot data suggest that topical MV can increase hair count and HMI by inducing WNT10B expression in the scalp, potentially serving as a novel treatment strategy for female AGA.

更新日期：2019-11-01

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