使用脐带图像分析仪（Cordial）可靠，快速地测量腰椎脊髓容积。,European Radiology

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使用脐带图像分析仪（Cordial）可靠，快速地测量腰椎脊髓容积。
European Radiology ( IF 4.7 ) Pub Date : 2018-05-02 , DOI: 10.1007/s00330-018-5431-1
Charidimos Tsagkas _{1,

2} , Anna Altermatt _{2,

3} , Ulrike Bonati ₄ , Simon Pezold ₃ , Julia Reinhard ₅ , Michael Amann _{1,

2,

5} , Philippe Cattin ₃ , Jens Wuerfel _{2,

3} , Dirk Fischer ₄ , Katrin Parmar ₁ , Arne Fischmann _{5,

6}

Affiliation

目的在健康对照者（HC）的3D T1w MRI数据中验证用于腰椎脊髓（SC）容积测量的半自动脐带图像分析仪（Cordial）的准确性和准确性。材料与方法在3台MRI扫描仪中，在两个MRI会话中（时间间隔14.9±6.1天）采集了40张10 HC的3D T1w图像（w / m：6/4；年龄范围：18-41岁）。每个对象在每个会话中扫描两次，从而可以确定背对背（会话内）和扫描-重新扫描图像（会话间）的重测可靠性。由两名评估者对每幅图像将Cordial应用于腰椎分割两次，以评估评估者内部和评估者之间的可靠性，并与手动黄金标准进行比较。结果虽然手动分割的体积更大（平均值：2028±245 mm3 vs.亲切的：1636±300 mm3，p <0.001），手动和半自动分割的图像之间的准确性评估显示平均Dice系数为0.88±0.05。受试者内部变异系数（COV）的计算显示了会话内（1.22-1.86％），会话间（1.26-1.84％）和评估者内（1.73-1.83％）的高可重复性。会话间和会话间的可重复性之间或评估者内的可靠性之间没有显着差异。尽管评分者之间的可重复性（COV：2.87％）比所有其他可重复性措施略低，但评分者之间的一致性非常强（类内相关系数：0.974）。结论虽然低估了腰椎SCV，Cordial仍具有出色的术中和术中可重复性，显示出在纵向试验中的巨大潜力。要点•使用半自动脐带图像分析仪（Cordial）进行腰椎脊髓分割是可行的。•腰椎脊髓位于距延髓上方60毫米的40毫米脊髓段。•Cordial在腰椎脊髓区域内提供良好的会话间和会话间重现性。•Cordial在纵向试验中显示出很高的潜力。

"点击查看英文标题和摘要"

Reliable and fast volumetry of the lumbar spinal cord using cord image analyser (Cordial).

OBJECTIVE To validate the precision and accuracy of the semi-automated cord image analyser (Cordial) for lumbar spinal cord (SC) volumetry in 3D T1w MRI data of healthy controls (HC). MATERIALS AND METHODS 40 3D T1w images of 10 HC (w/m: 6/4; age range: 18-41 years) were acquired at one 3T-scanner in two MRI sessions (time interval 14.9±6.1 days). Each subject was scanned twice per session, allowing determination of test-retest reliability both in back-to-back (intra-session) and scan-rescan images (inter-session). Cordial was applied for lumbar cord segmentation twice per image by two raters, allowing for assessment of intra- and inter-rater reliability, and compared to a manual gold standard. RESULTS While manually segmented volumes were larger (mean: 2028±245 mm3 vs. Cordial: 1636±300 mm3, p<0.001), accuracy assessments between manually and semi-automatically segmented images showed a mean Dice-coefficient of 0.88±0.05. Calculation of within-subject coefficients of variation (COV) demonstrated high intra-session (1.22-1.86%), inter-session (1.26-1.84%), as well as intra-rater (1.73-1.83%) reproducibility. No significant difference was shown between intra- and inter-session reproducibility or between intra-rater reliabilities. Although inter-rater reproducibility (COV: 2.87%) was slightly lower compared to all other reproducibility measures, between rater consistency was very strong (intraclass correlation coefficient: 0.974). CONCLUSION While under-estimating the lumbar SCV, Cordial still provides excellent inter- and intra-session reproducibility showing high potential for application in longitudinal trials. KEY POINTS • Lumbar spinal cord segmentation using the semi-automated cord image analyser (Cordial) is feasible. • Lumbar spinal cord is 40-mm cord segment 60 mm above conus medullaris. • Cordial provides excellent inter- and intra-session reproducibility in lumbar spinal cord region. • Cordial shows high potential for application in longitudinal trials.

更新日期：2018-04-30

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