INTRODUCTION During the last 3 decades, the standard treatment for stage Ia2-Ib1 cervical cancer has been Piver-Rutledge class II or III radical hysterectomy. However, this surgery is associated with a high rate of urologic morbidity. AIM To determine the efficacy of class I radical hysterectomy compared with class III radical hysterectomy in terms of morbidity, overall survival, and patterns of relapse in patients with Ia2-Ib1 cervical cancer undergoing primary surgery. MATERIAL AND METHODS A total of 101 patients with stage Ia2-Ib1 cervical cancer < 2 cm were randomized to class I and class III hysterectomy groups. Clinical, pathologic, and follow-up data were prospectively collected. Univariate analysis was carried out. Of the total patients, 45 were randomized to class I surgery and 56 to class III surgery. No significant differences were observed in terms of pathologic findings or adjuvant treatment (p > 0.05). The morbidity rates were higher after class III surgery. RESULTS The difference in recurrence rate between the class I and class III groups was not statistically significant (p > 0.05). The 5-year overall survival rate was 93% and 91%, respectively (p > 0.05). There were no significant differences in terms of recurrence rate or overall survival among patients with stage Ia2-Ib1 cervical cancer < 2 cm who underwent class I or radical (class III) hysterectomy. Morbidity was proportional to the extent of radicality. CONCLUSIONS These data confirm the need for reducing surgical radicality in the treatment of patients with early cervical cancer, by tailoring the extent of resection according to the extent of disease.

中文翻译：

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Ia2-Ib1 期宫颈癌的 I 类子宫切除术。

引言 在过去 3 年中，Ia2-Ib1 期宫颈癌的标准治疗方法是 Piver-Rutledge II 或 III 级根治性子宫切除术。然而，这种手术与泌尿系统的高发病率有关。目的 比较 Ia2-Ib1 宫颈癌初次手术患者的发病率、总生存期和复发模式，确定 I 类根治性子宫切除术与 III 类根治性子宫切除术的疗效。材料与方法 101 例 Ia2-Ib1 期宫颈癌 < 2 cm 患者被随机分为 I ​​类和 III 类子宫切除术组。前瞻性收集临床、病理和随访数据。进行了单变量分析。在所有患者中，45 名被随机分配至 I 级手术，56 名被随机分配至 III 级手术。在病理结果或辅助治疗方面没有观察到显着差异（p > 0.05）。III级手术后的发病率较高。结果Ⅰ类和Ⅲ类组的复发率差异无统计学意义（p>0.05）。5 年总生存率分别为 93% 和 91% (p > 0.05)。Ia2-Ib1 期宫颈癌 < 2 cm 患者接受 I 类或根治性（III 类）子宫切除术的复发率或总生存率无显着差异。发病率与激进程度成正比。结论 这些数据证实需要通过根据疾病程度调整切除范围来减少早期宫颈癌患者治疗中的手术根治性。