鼠李糖嗪对脂多糖引起的大鼠急性肺损伤和炎症的抗氧化剂和抗炎作用。,Africa Journal of Traditional Complementary and Alternative Medicine

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鼠李糖嗪对脂多糖引起的大鼠急性肺损伤和炎症的抗氧化剂和抗炎作用。
Africa Journal of Traditional Complementary and Alternative Medicine Pub Date : 2017-06-24 , DOI: 10.21010/ajtcam.v14i4.23
GuoRong Wu ₁ , XiaoPing Dai ₁ , XiangRong Li ₁ , HePing Jiang ₁

Affiliation

背景技术急性肺损伤（ALI）导致严重的炎症和对肺组织的氧化应激。Rhamnazin是一种天然类黄酮，以其抗氧化和抗炎特性而闻名。材料和方法测试了鼠李糖苷的抗氧化和抗炎特性，可预防急性肺损伤。我们调查了鼠李糖嗪是否能改善动物模型（大鼠）中脂多糖（LPS）诱导的ALI。我们还研究了鼠李糖苷作用的可能分子机理。在气管内LPS攻击（5mg / kg）前两天，腹膜内（ip）（5、10和20 mg / kg）注射Rhamnazin。估算了肺干重比，LDH活性，肺组织病理学，BALF蛋白浓度，MPO活性，氧化应激，细胞因子产生的变化。结果结果显示，用鼠李糖苷预处理的动物组所有炎症参数均明显减轻，肺组织病理学显着改善。鼠李糖嗪预处理组还显示出Nrf2途径的激活和ROS（如H2O2，MDA和氢氧根离子）的减弱。这些结果表明，鼠李糖嗪由于其强大的抗氧化和抗炎特性，可以减轻大鼠的ALI症状。结论该结果强烈证明鼠李糖苷对LPS诱导的ALI具有保护作用。其抗炎作用的潜在机制可能包括抑制Nrf2介导的抗氧化途径。

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ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF RHAMNAZIN ON LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY AND INFLAMMATION IN RATS.

BACKGROUND Acute Lung Injury (ALI) results into severe inflammation and oxidative stress to the pulmonary tissue. Rhamnazin is a natural flavonoid and known for its antioxidant and anti-inflammatory properties. MATERIALS AND METHODS The antioxidative and anti-inflammatory properties rhamnazin were tested for protection against the acute lung injury. We investigated whether rhamnazin improves the lipopolysaccharide (LPS)-induced ALI in an animal model (rat). We also studied the probable molecular mechanism of action of rhamnazin. Rhamnazin was injected intraperitoneally (i.p.) (5, 10 and 20 mg/kg) two days before intratracheal LPS challenge (5mg/kg). The changes in lung wet-to-dry weight ratio, LDH activity, pulmonary histopathology, BALF protein concentration, MPO activity, oxidative stress, cytokine production were estimated. RESULTS The results showed a significant attenuation of all the inflammatory parameters and a marked improvement in the pulmonary histopathology in the animal groups pretreated with rhamnazin. The rhamnazin pretreated group also showed activation of Nrf2 pathway and attenuation of ROS such as H2O2, MDA and hydroxyl ion. These results indicated that rhamnazin could attenuate the symptoms of ALI in rats due to its strong antioxidant and anti-inflammatory properties. CONCLUSION The results strongly demonstrated that rhamnazin provides protection against LPS-induced ALI. The underlying mechanisms of its anti-inflammatory action may include inhibition of Nrf2 mediated antioxidative pathway.

更新日期：2019-11-01

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