在计算机上鉴定和表征人FOXN5和大鼠Foxn5基因。,International Journal of Oncology

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在计算机上鉴定和表征人FOXN5和大鼠Foxn5基因。
International Journal of Oncology ( IF 4.5 ) Pub Date : 2004-04-07
Masuko Katoh ₁ , Masaru Katoh

Affiliation

前叉箱基因（FOX）通过依赖SHH-GLI途径，TGF-β途径等的转录调控参与胚胎发生，并通过基因扩增，逆转录病毒整合和染色体易位参与癌变。FOXN1，FOXN2（HTLF），FOXN3（CHES1）和FOXN4构成FOXN家族。在这里，我们通过使用生物信息学鉴定并表征了FOXN5基因家族的新成员FOXN5基因。IMAGE5167039（BC028191.1）是源自人FOXN5基因的代表性cDNA。在大鼠基因组序列CH230-26K11（AC107575.5）中鉴定到了由六个外显子组成的Rat Foxn5基因。通过组装大鼠Foxn5外显子的核苷酸序列确定大鼠Foxn5 cDNA的完整编码序列。人FOXN5（292 aa）和大鼠Foxn5（296 aa）显示77.4％的总氨基酸同一性。FOXN5的密码子173-254是Forkhead域。由六个外显子组成的FOXN5基因在人染色体11q23.3与BCL9L基因连锁。FOXN5是候选肿瘤抑制基因（TSG），与ARHGAP20（KIAA1391），BTG4，SNF1LK2（SIK2），DIXDC1（KIAA1735）基因位于11q23.1、11q23.2具有TTC12（TPARM）基因，IGSF4，DSCAML1，LL5A （PHLDB1），BCL9L，RNF26和MFRP基因位于11q23.3。这是关于人类FOXN5和大鼠Foxn5基因的首次报道。

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Identification and characterization of human FOXN5 and rat Foxn5 genes in silico.

Forkhead-box (FOX) genes are implicated in embryogenesis through transcriptional regulation depending on SHH-GLI pathway, TGF-beta pathway etc., and also in carcinogenesis through gene amplification, retroviral integration and chromosomal translocation. FOXN1, FOXN2 (HTLF), FOXN3 (CHES1) and FOXN4 constitute the FOXN family. Here, we identified and characterized the FOXN5 gene, a novel member of FOXN gene family, by using bioinformatics. IMAGE5167039 (BC028191.1) was the representative cDNA derived from human FOXN5 gene. Rat Foxn5 gene, consisting of six exons, was identified within rat genome sequence CH230-26K11 (AC107575.5). Complete coding sequence of rat Foxn5 cDNA was determined by assembling nucleotide sequences of rat Foxn5 exons. Human FOXN5 (292 aa) and rat Foxn5 (296 aa) showed 77.4% total-amino-acid identity. Codon 173-254 of FOXN5 was the Forkhead domain. FOXN5 gene, consisting of six exons, was linked to BCL9L gene at human chromosome 11q23.3. FOXN5 is a candidate tumor suppressor gene (TSG), just like ARHGAP20 (KIAA1391), BTG4, SNF1LK2 (SIK2), DIXDC1 (KIAA1735) genes at 11q23.1, TTC12 (TPARM) gene at 11q23.2, IGSF4, DSCAML1, LL5A (PHLDB1), BCL9L, RNF26, and MFRP genes at 11q23.3. This is the first report on the human FOXN5 and rat Foxn5 genes.

更新日期：2019-11-01

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