The application of human pediatric equipment for measuring respiratory function in nonhuman primates is rapidly gaining popularity in the evaluation of anti-asthma drugs. An important difference between primate procedures and the human clinical situation is the requirement for anesthesia for some techniques because of poor animal compliance. We studied the actions of three potential maintenance anesthetic agents-thiopental, saffan, and propofol-and their effects on a range of cardiovascular parameters under conditions of a broncho-provocation test in rhesus monkeys. The spasmolytic effect of saffan on bronchial smooth muscle was investigated in smooth muscle preparations in vitro and in the rhesus monkey in vivo. Thiopental proved to be a useful sedating agent for this application. Saffan proved to be a bronchodilator in vitro, but the sedative dose was lower than that required to induce appreciable bronchodilator activity in vivo. In comparison, propofol was not appropriate for this application because of the poor sedative effect at nonbronchodilator doses.

中文翻译：

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硫喷妥钠，番红花和丙泊酚麻醉对恒河猴心血管参数和支气管平滑肌的影响。

在非哮喘灵长类动物的评估中，用于测量非人类灵长类动物呼吸功能的人类儿童设备的应用正在迅速普及。灵长类动物手术与人类临床情况之间的重要区别是，由于动物顺应性差，某些技术需要麻醉。我们研究了三种潜在的维持麻醉药（硫喷妥钠，藏红花和丙泊酚）的作用，以及它们在恒河猴的支气管激发试验条件下对一系列心血管参数的影响。在体外和恒河猴体内，番红花对支气管平滑肌的痉挛作用进行了研究。硫喷妥钠已被证明是该应用中有用的镇静剂。事实证明，Saffan是一种支气管扩张剂，但镇静剂量低于在体内诱导明显的支气管扩张剂活性所需的剂量。相比之下，丙泊酚不适用于该应用，因为在非支气管扩张剂剂量下镇静效果较差。