Neutrophils isolated from the pleural cavity of rats 3 hr after the intrapleural injection of carrageenan metabolize exogenously added arachidonic acid via cyclooxygenase and lipoxygenase. In addition, these cells esterify arachidonic acid to produce diarachidonyl diglyceride. The structure of the diglyceride was determined with the use of various chemical and enzymatic digestions, gas chromatography-mass spectrometry, and 252Cf plasma-desorption mass spectrometry. The formation of this unique diglyceride is stimulated by the presence of nonsteroidal anti-inflammatory drugs. Some of the possible consequences of diarachidonyl diglyceride production are discussed.

中文翻译：

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大鼠中性粒细胞形成花生四烯酸二甘油酯。

胸膜内注射角叉菜胶后3小时从大鼠胸腔分离的嗜中性粒细胞通过环氧合酶和脂氧合酶代谢外源添加的花生四烯酸。另外，这些细胞酯化花生四烯酸以产生花生四烯酸二甘油酯。使用各种化学和酶消化，气相色谱-质谱和252Cf等离子体解吸质谱法确定甘油二酯的结构。非甾体类抗炎药的存在会刺激这种独特的甘油二酸酯的形成。讨论了花生四烯酸二甘油酯生产的一些可能后果。