从枸杞果实中分离的天然维生素 C 类似物 2-O-β-D-吡喃葡萄糖基-L-抗坏血酸的抗氧化作用的比较评价,Archives of Pharmacal Research

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从枸杞果实中分离的天然维生素 C 类似物 2-O-β-D-吡喃葡萄糖基-L-抗坏血酸的抗氧化作用的比较评价
Archives of Pharmacal Research ( IF 6.9 ) Pub Date : 2011-05-01 , DOI: 10.1007/s12272-011-0514-4
Ziping Zhang ₁ , Xiaoming Liu , Xu Zhang , Junhong Liu , Yanfang Hao , Xueyun Yang , Yujiong Wang

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摘要 2-O-β-D-吡喃葡萄糖基-L-抗坏血酸（AA-2βG）是从枸杞（Lycium barbarum L.）果实中分离得到的维生素C（Lacorbic acid，AA）的天然衍生物。我们使用体外和体内模型系统评估了 AA-2βG 和 AA 的抗氧化活性。体外自由基清除试验表明，AA-βG 能够清除 1,1-diphenyl-2-picryl-hydrazyl 和过氧化氢，并能比 AA 更好地抑制 H2O2 诱导的溶血。AA-2βG和AA具有相似的羟基自由基清除能力，但AA-2βG不能清除超氧阴离子自由基，其清除亚硝酸盐(NO2-)的能力低于AA。AA-2βG 的整体体外还原能力也显着低于 AA。而且，体内研究表明，AA-2βG 能够保护肝脏免受四氯化碳诱导的小鼠急性肝损伤。这些结果表明 AA-2βG 是枸杞果实的重要抗氧化成分，其可能与 AA 具有相似但不同的抗氧化机制特性。本研究进一步加深了我们对枸杞果实作为传统药物和膳食补充剂的抗衰老和抗肿瘤特性的药理活性机制的理解。

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Comparative evaluation of the antioxidant effects of the natural vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from Goji berry fruit

Abstract2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG) is a natural derivative of vitamin C (Lascorbic acid, AA) isolated from Goji berry (Lycium barbarum L.) fruit. We evaluated the antioxidant activities of AA-2βG and AA using in vitro and in vivo model systems. In vitro radical scavenging assays demonstrated that AA-βG was capable of scavenging 1,1-diphenyl-2-picryl-hydrazyl and hydroxyl peroxide and inhibiting H2O2-induced hemolysis better than AA. AA-2βG and AA had similar hydroxyl radical scavenging capabilities, but AA-2βG was incapable of scavenging superoxide anion radicals, and its capacity to scavenge nitrite (NO2−) was lower than that of AA. The overall in vitro reduction capability of AA-2βG was also significantly lower than that of AA. Moreover, in vivo studies demonstrated that AA-2βG was capable of protecting the liver against carbon tetrachloride-induced acute liver injury in mice. These results suggest that AA-2βG is an important antioxidant component of Goji berry fruit, which may share similar but distinct antioxidant mechanistic properties with AA. This study furthers our understanding of the mechanisms of Goji berry fruit pharmacological activities on antiaging and antitumor properties as a traditional medicine and dietary supplement.

更新日期：2011-05-01

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