Schiff bases (9a-l) of 3-amino-6,8-dibromo-2-phenyl-quinazolin-4-(3H)-ones (8) with various substituted aldehydes were obtained by refluxing 1:1 molar equivalents of the reactants in dry ethanol for 6 h. The aminoquinazoline (8) was inturn obtained from 3,5-dibromoantharlinic acid via intermediate (7). All the synthesized compounds (9a-l) were evaluated for their anticonvulsant activity on albino mice by maximal electroshock method using phenytoin as a standard. The compound (9l) bearing a cinnamyl function displays a very high activity (82.74 %) at dose level of 100 mg/kg b.w.

中文翻译：

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3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones 席夫碱的抗惊厥活性。

通过回流 1:1 摩尔当量的反应物，获得 3-氨基-6,8-二溴-2-苯基-喹唑啉-4-(3H)-酮 (8) 与各种取代醛的席夫碱 (9a-l)在无水乙醇中 6 小时。氨基喹唑啉 (8) 又通过中间体 (7) 从 3,5-二溴蒽啉酸获得。使用苯妥英作为标准，通过最大电击法评估所有合成的化合物(9a-1)对白化病小鼠的抗惊厥活性。具有肉桂基功能的化合物 (9l) 在 100 mg/kg bw 的剂量水平显示出非常高的活性 (82.74 %)