The activation of hexadecanedioic acid has been studied in subcellular fractions of human liver. The activation capacity in a total homogenate of human liver was found to be 0.5 micro mole/min/g wet wt of tissue, about 10% of that for palmitic acid. Hexadecanedioic acid was activated by the mitochondrial and microsomal fractions. The mitochondrial enzyme is probably localized outside the inner mitochondrial compartment. The subcellular distribution of the hexadecanedioic acid activation was almost identical with the distribution of palmitic acid activation. Hexadecanedioic and palmitic acids seemed to compete for the same enzyme.

中文翻译：

---

人肝中十六烷二酸活化的亚细胞定位。

十六烷二酸的活化已在人肝的亚细胞部分中进行了研究。发现人肝的总匀浆中的活化能力为0.5微摩尔/分钟/克组织的湿重，约为棕榈酸的活化能力的10％。十六烷二酸被线粒体和微粒体级分活化。线粒体酶可能位于线粒体内壁的外部。十六烷二酸活化的亚细胞分布与棕榈酸活化的分布几乎相同。十六烷二酸和棕榈酸似乎竞争相同的酶。