Intestinal permeability to size-classified fish collagen peptides (FCPs) was examined using Caco-2 monolayers. Minimum-sized FCPs were most efficiently transported across the Caco-2 monolayers. Permeability depended on peptide size. It was independent of the H(+)-coupled peptide transport system but was associated with tight junction permeability, suggesting that the paracellular pathway is responsible for transepithelial transport of collagen peptides.

中文翻译：

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胶原蛋白肽的分子大小逆转了Caco-2细胞的通透性。

使用Caco-2单层膜检查了肠道对大小分类鱼胶原蛋白肽（FCP）的通透性。最小尺寸的FCP最有效地跨Caco-2单层运输。渗透性取决于肽的大小。它独立于H（+）耦合的肽运输系统，但与紧密的连接渗透性相关联，表明细胞旁通路负责胶原肽的上皮运输。