Folium Eriobotryae has been used as a medicinal plant for a long time, and it is known to have many physiological actions such as anti-inflammatory, anti-tussive, expectorant and anti-diabetic. We have reported that the 70% ethanol extract of Folium Eriobotryae exerted a significant hypoglycemic effect to alloxan-diabetic mice. In this study, we isolated euscaphic acid, a natural product from Folium Eriobotryae, and investigated its hypoglycemic effect in normoglycemic and alloxan-diabetic mice. All effects had been compared with those of gliclazide. The plasma glucose levels were significantly lowered in normoglycemic mice treated with euscaphic acid compared to mice treated with 0.5% CMC-Na solution only. Moreover, the dosage of 50 mg/kg exerted a significant (P < 0.05) hypoglycemic effect in alloxan-diabetic mice after orally administration. The research proved that euscaphic acid is one of the active hypoglycemic constituents in Folium Eriobotryae, but the details of the mechanism need to be investigated further.

中文翻译：

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Euscaphic acid，一种来自叶草的新的降血糖天然产物。

大叶艾草已被用作药用植物很长一段时间，并且已知具有许多生理作用，例如抗炎，镇咳，祛痰和抗糖尿病。我们已经报道了大叶草的70％乙醇提取物对四氧嘧啶糖尿病小鼠具有显着的降血糖作用。在这项研究中，我们分离了叶番莲叶的天然产物硫辛酸，并研究了其在正常血糖和四氧嘧啶糖尿病小鼠中的降血糖作用。将所有效果与格列齐特的效果进行了比较。与仅用0.5％CMC-Na溶液治疗的小鼠相比，用大黄酸治疗的血糖正常的小鼠血浆葡萄糖水平显着降低。此外，口服阿洛生后，50 mg / kg的剂量对糖尿病小鼠具有显着的降血糖作用（P <0.05）。