Sarafotoxin S6b, a strong vasocontractile peptide with 21 amino acid residues containing two sets of disulfide bridges, was chemically synthesized. The retention time on a reversed-phase HPLC, lethal and vasocontractile activities of natural sarafotoxin S6b agree with those of the synthetic [Cys1-15, Cys3-11]-sarafotoxin S6b. The combination of the disulfide bridges of sarafotoxin S6b is the same as that of endothelin-1, a mammalian vasocontractile peptide, which shows a high degree of sequence homology and shares several common pharmacological properties with sarafotoxins.

中文翻译：

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sarafotoxins二硫键的研究。sarafotoxin S6B的化学合成及其具有不同二硫键的同系物。

化学合成了Sarafotoxin S6b，它是一种具有21个氨基酸残基的强血管收缩肽，含有两组二硫键。天然sarafotoxin S6b的反相HPLC保留时间，致死性和血管收缩活性与合成的[Cys1-15，Cys3-11] -sarafotoxin S6b的保留时间一致。sarafotoxin S6b的二硫键与内皮素-1（一种哺乳动物的血管收缩肽）的结合相同，它具有高度的序列同源性，并且与sarafotoxins具有一些共同的药理特性。