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[New derivatives of 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepine-11-ones with anticholinergic activity].
Die Pharmazie Pub Date : 1990-07-01 C Rüger 1 , H Röhnert , D Lohmann
Die Pharmazie Pub Date : 1990-07-01 C Rüger 1 , H Röhnert , D Lohmann
Affiliation
Starting from 2-aminobenzoic acid and correspondingly substituted 2-chloronitrobenzenes, 5-substituted-aminoacyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin -11- one derivatives with a differently high activity on ulcers were prepared. 8-Chloro-5,10-dihydro-5-[bis(2-hydroxyethyl)a-minoacetyl]-11H- dibenzo[b,e][1,4]diazepin-11-one hydrochloride (AWD 26-06) was selected for further clinical evaluation.
中文翻译:
[具有抗胆碱活性的5,10-二氢-11H-二苯并[b,e] [1,4]二氮杂-11-酮的新衍生物]。
从2-氨基苯甲酸和相应取代的2-氯硝基苯开始,5-取代-氨基酰基-5,10-二氢-11H-二苯并[b,e] [1,4]二氮杂pin-11-具有一种高活性的衍生物准备好溃疡。8-氯-5,10-二氢-5- [双(2-羟乙基)α-氨基乙酰基] -11H-二苯并[b,e] [1,4]二氮杂-11-一盐酸盐(AWD 26-06)为选择进行进一步的临床评估。
更新日期:2019-11-01
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
[具有抗胆碱活性的5,10-二氢-11H-二苯并[b,e] [1,4]二氮杂-11-酮的新衍生物]。
从2-氨基苯甲酸和相应取代的2-氯硝基苯开始,5-取代-氨基酰基-5,10-二氢-11H-二苯并[b,e] [1,4]二氮杂pin-11-具有一种高活性的衍生物准备好溃疡。8-氯-5,10-二氢-5- [双(2-羟乙基)α-氨基乙酰基] -11H-二苯并[b,e] [1,4]二氮杂-11-一盐酸盐(AWD 26-06)为选择进行进一步的临床评估。