The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-12, and 14-17 exhibited inhibition (IC50 ≤ 7.31 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9-11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values ≤7.83 µg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.

中文翻译：

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来自 Cnidium monnieri 果实的新香豆素和抗炎成分。

蛇床子的果实在商业上用作保健品，用于改善阳痿和皮肤病。三种新香豆素，3'-O-methylmurraol (1)、rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2) 和 (1'S,2'S)-1'-O-methylvaginol (3)，具有从 C. monnieri 的果实中分离出 14 种已知化合物 (4-17)。这些新化合物的结构是通过光谱和 MS 分析确定的。化合物 1、4-12 和 14-17 表现出抑制 (IC50 ≤ 7.31 µg/mL) 人中性粒细胞响应甲酰基-l-甲硫氨酰基-l-亮氨酰基-l-苯丙氨酸/细胞松弛素 B (fMLP/ CB）。化合物 7、9-11、15 和 17 抑制 fMLP/CB 诱导的弹性蛋白酶释放，IC50 值≤7.83 µg/mL。该调查表明，生物活性分离株（尤其是 6、7、14、