<br>CTXA 髋关节——使用定量 CT 的经典 DXA 测量的延伸。,PLOS ONE

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CTXA 髋关节——使用定量 CT 的经典 DXA 测量的延伸。
PLOS ONE ( IF 2.9 ) Pub Date : 2014-03-17 , DOI: 10.1371/journal.pone.0091904
Christopher E Cann ₁ , Judith E Adams ₂ , J Keenan Brown ₃ , Alan D Brett ₃

Affiliation

使用双能 X 射线吸收测定法 (DXA) 估算股骨近端骨矿物质密度 (BMD) 目前被认为是仅使用 BMD 诊断个体患者骨质疏松症的标准。我们将商业定量 CT (QCT) BMD 分析系统“CTXA Hip”（提供股骨近端的临床数据）的 BMD 结果与 DXA 结果进行了比较。我们还使用 CTXA 髋关节来确定皮质和小梁对总 BMD 的贡献。使用 3D QCT 和 DXA 对 69 名患者进行了扫描。将 CTXA 髋部 BMD 测量的总髋部和股骨颈与 DXA 结果进行比较。 22 名女性在 0、1、2 岁时进行了扫描，并对 CTXA 髋关节和 DXA 结果进行了长期可重复性分析。与 0.014 g 相比，以体内 SD 均方根平均值计算的长期重现性为 0.012 g/cm2 (CV = 1.8%)，CTXA 全髋关节为 0.011 g/cm2 (CV = 2.0%)，CTXA 股骨颈为 0.011 g/cm2 (CV = 2.0%)对于 DXA，分别为 /cm2 (CV = 2.0%) 和 0.016 g/cm2 (CV = 2.7%)。总髋部 BMD CTXA 与 DXA 的相关性为 R = 0.97，股骨颈的相关性为 R = 0.95（两种情况下的 SEE 均为 0.044 g/cm2）。骨质疏松女性的皮质骨占髋骨总质量的 62±5%（平均值±标准差）。 CTXA 髋关节提供与传统 DXA 基本相同的临床信息，此外还提供单独皮质骨和小梁骨室中 BMD 的估计，这可能有助于评估骨强度。

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CTXA hip--an extension of classical DXA measurements using quantitative CT.

Bone mineral density (BMD) estimates for the proximal femur using Dual Energy X-ray Absorptiometry (DXA) are currently considered the standard for making a diagnosis of osteoporosis in an individual patient using BMD alone. We have compared BMD results from a commercial Quantitative CT (QCT) BMD analysis system, "CTXA Hip", which provides clinical data for the proximal femur, to results from DXA. We have also used CTXA Hip to determine cortical and trabecular contributions to total BMD. Sixty-nine patients were scanned using 3D QCT and DXA. CTXA Hip BMD measurements for Total Hip and Femoral Neck were compared to DXA results. Twenty-two women were scanned at 0, 1, 2 years and CTXA Hip and DXA results analyzed for long-term reproducibility. Long-term reproducibility calculated as root-mean-square averages of SDs in vivo was 0.012 g/cm2 (CV = 1.8%) for CTXA Total Hip and 0.011 g/cm2 (CV = 2.0%) for CTXA Femoral Neck compared to 0.014 g/cm2 (CV = 2.0%) and 0.016 g/cm2 (CV = 2.7%), respectively, for DXA. The correlation of Total Hip BMD CTXA vs. DXA was R = 0.97 and for Femoral Neck was R = 0.95 (SEE 0.044 g/cm2 in both cases). Cortical bone comprised 62±5% (mean ± SD) of total hipbone mass in osteoporotic women. CTXA Hip provides substantially the same clinical information as conventional DXA and in addition provides estimates of BMD in separate cortical and trabecular bone compartments, which may be useful in evaluation of bone strength.

更新日期：2019-11-01

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