The acaricidal activity of the 9-oxo-10,11-dehydroageraphorone (euptox A), a cadenine sesquiterpene from Eupatorium adenophorum (E. adenophorum) against Sarcoptes scabiei and Psoroptes cuniculi was tested in vitro. A complementary log-log (CLL) model was used to analyze the data of the toxicity tests in vitro. The results showed euptox A had strong toxicity against mites, killing all S. scabiei at 3 and 4 mg/ml (m/v) concentration, while 4 mg/ml euptox A was also found to kill all P. cuniculi within a 4 h period. Similarly, 2, 3 and 4 mg/ml concentration of euptox A had strong toxicity against S. scabiei, with median lethal time (LT50) values at 0.687, 0.526, 0.326 h, respectively. 3 mg/ml and 4 mg/ml showed strong acaricidal action against P. cuniculi; the LT50 values were 0.693 and 0.493 h, respectively. The median lethal concentration (LC50) values were 1.068 mg/ml for Scabies mite and 0.902 mg/ml for P. cuniculi in 2 h. The results indicate that euptox A has strong acaricidal activity and may exploit as novel drugs for the effective control of animal acariasis.

中文翻译：

---

从紫茎泽兰中提取的9-oxo-10,11-dehydroageraphorone的体外杀螨活性。

在体外测试了9-oxo-10,11-dehydroageraphorone（euptox A），一种来自紫茎泽兰（E. adenophorum）的高嘌呤倍半萜烯对Sarcoptes scabiei和Psoroptes cuniculi的杀​​螨活性。互补对数-对数（CLL）模型用于分析体外毒性试验的数据。结果表明，euptox A对螨有很强的毒性，以3和4 mg / ml（m / v）的浓度杀死所有scabiei链球菌，同时还发现4 mg / ml euptox A在4小时内杀死了所有的库氏假单胞菌。期。同样，浓度为2、3和4 mg / ml的euptox A对S. scabiei有很强的毒性，致死时间（LT50）的中值分别为0.687、0.526、0.326 h。3 mg / ml和4 mg / ml对黄瓜青枯菌有很强的杀螨作用。LT50值分别为0.693和0.493 h。在2小时内，Sc螨的致命致死浓度（LC50）值中位数为1.068 mg / ml，枯萎病为0.902 mg / ml。结果表明，e毒素A具有很强的杀螨活性，可以作为新型药物有效控制动物虫病。