Ionizing radiation can induce cellular oxidative stress through the generation of reactive oxygen species, resulting in cell damage and cell death. The aim of this study was to determine whether the antioxidant effects of the flavonoid fisetin (3,7,3',4'-tetrahydroxyflavone) included the radioprotection of cells exposed to γ-irradiation. Fisetin reduced the levels of intracellular reactive oxygen species generated by γ-irradiation and thereby protected cells against γ-irradiation-induced membrane lipid peroxidation, DNA damage, and protein carbonylation. In addition, fisetin maintained the viability of irradiated cells by partially inhibiting γ-irradiation-induced apoptosis and restoring mitochondrial membrane potential. These effects suggest that the cellular protective effects of fisetin against γ-irradiation are mainly due to its inhibition of reactive oxygen species generation.

中文翻译：

---

鱼腥草素（3,7,3',4'-四羟基黄酮）对γ-辐射诱导的氧化应激和细胞损伤的保护作用。

电离辐射可通过产生活性氧来诱导细胞氧化应激，导致细胞损伤和细胞死亡。本研究的目的是确定黄酮类漆黄酮（3,7,3',4'-四羟基黄酮）的抗氧化作用是否包括暴露于 γ 辐射的细胞的辐射防护。鱼腥草素降低了由 γ 辐射产生的细胞内活性氧的水平，从而保护细胞免受 γ 辐射诱导的膜脂过氧化、DNA 损伤和蛋白质羰基化。此外，非瑟酮通过部分抑制γ-辐射诱导的细胞凋亡和恢复线粒体膜电位来维持受辐射细胞的活力。