A series of poly(anhydride-esters) based on poly(1,10-bis(o-carboxyphenoxy)decanoate) (CPD) and poly(1,6-bis(p-carboxyphenoxy)hexane) (p-CPH) were synthesized by melt-condensation polymerization. Poly-(anhydride-esters) that contain CPD hydrolytically degraded into salicylic acid, however, these homopolymers have mechanical and thermal characteristics that limit their use in clinical applications. The synthesis and characterization of copolymers of CPD with p-CPH, a monomer known to generate mechanically stable homopolymers, was investigated. By changing the CPD to p-CPH monomer ratios, the salicylic acid loading and thermal/mechanical properties of the copolymers was a controlling factor; increasing the CPD concentration increased the salicylate loading but decreased the polymer stability; whereas increasing the p-CPH concentration increased the thermal and mechanical stability of the copolymers. Specifically, decreasing the CPD:p-CPH ratio resulted in lower salicylate loading and increased thermal decomposition temperatures. The glass transition temperatures (°C) varied from 27 to 38°C, a desirable range for elastomeric biomedical implants.

中文翻译：

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水杨酸基聚(酸酐-酯)共聚物的合成与表征

合成了一系列基于聚（1,10-双（邻羧基苯氧基）癸酸酯）（CPD）和聚（1,6-双（对羧基苯氧基）己烷）（p-CPH）的聚（酐-酯）通过熔融缩聚。含有水解降解为水杨酸的 CPD 的聚（酸酐酯），然而，这些均聚物具有机械和热特性，限制了它们在临床应用中的使用。研究了 CPD 与 p-CPH 的共聚物的合成和表征，p-CPH 是一种已知可产生机械稳定均聚物的单体。通过改变 CPD 与 p-CPH 单体的比例，共聚物的水杨酸负载量和热/机械性能是一个控制因素；增加 CPD 浓度会增加水杨酸盐的负载量，但会降低聚合物的稳定性；而增加 p-CPH 浓度会增加共聚物的热稳定性和机械稳定性。具体而言，降低 CPD:p-CPH 比率导致较低的水杨酸盐负载和增加的热分解温度。玻璃化转变温度 (°C) 在 27 至 38°C 之间变化，这是弹性生物医学植入物的理想范围。