The use of the tert-butyloxycarbonyl (Boc) as the Nα-amino protecting group in peptide synthesis can be advantageous in several cases, such as synthesis of hydrophobic peptides and peptides containing ester and thioester moieties. The primary challenge of using Boc SPPS is the need for treatment of the resin-bound peptide with hazardous hydrogen fluoride (HF), which requires special equipment.

中文翻译：

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使用叔丁氧羰基（Boc）作为α-氨基保护基的肽的合成。

在肽合成中使用叔丁氧羰基（Boc）作为Nα-氨基保护基在几种情况下可能是有利的，例如疏水肽和含有酯和硫酯部分的肽的合成。使用Boc SPPS的主要挑战是需要使用危险的氟化氢（HF）处理与树脂结合的肽，这需要特殊的设备。