奥扎格雷对实验动物模型短暂性脑缺血后运动和运动协调的影响,Pharmacology

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奥扎格雷对实验动物模型短暂性脑缺血后运动和运动协调的影响
Pharmacology ( IF 2.9 ) Pub Date : 1999-01-01 , DOI: 10.1159/000028328
K Ichikawa ₁ , S Tazawa , S Hamano , M Kojima , S Hiraku

Affiliation

在实验动物模型中研究了选择性血栓素 A2 (TXA2) 合成酶抑制剂奥扎格雷对脑缺血再灌注后梗阻的影响。在有意识的脑缺血再灌注小鼠模型中，通过给予奥扎格雷改善了自发运动活动的减少和运动协调的障碍。Ozagrel在清醒脑缺血再灌注SHR模型中抑制了闭塞再灌注引起的脑组织比重下降，恢复了猫大脑中动脉闭塞再灌注后皮层PO2的缺血后下降。脑缺血再灌注后脑中TXB2（TXA2的代谢物）水平升高，奥扎格雷阻止了这种升高。此外，ozagrel 还增加了 6-keto-PGF1α 的水平，脑缺血再灌注后脑组织中前列腺素 I2 (PGI2) 的一种代谢物，并且 PGI2 的给药改善了有意识的脑缺血再灌注小鼠模型中自发运动活动的降低。我们的数据表明，奥扎格雷通过阻止 TXA2 的增加和导致 PGI2 水平的增加来保护脑血流，从而抑制了脑缺血再灌注后的梗阻。

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Effect of Ozagrel on Locomotor and Motor Coordination after Transient Cerebral Ischemia in Experimental Animal Models

The effect of ozagrel, a selective thromboxane A2 (TXA2) synthetase inhibitor, on the obstruction after cerebral ischemia-reperfusion was studied in experimental animal models. The reduced spontaneously locomotor activity and the obstruction of motor coordination were improved by the administration of ozagrel in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel suppressed the decrease in specific gravity of the brain tissue induced by the occlusion-reperfusion in the conscious cerebral ischemia-reperfusion SHR model, and recovered the postischemic decrease in cortical PO2 after middle cerebral artery occlusion-reperfusion in cats. The level of TXB2, a metabolite of TXA2, in the brain increased after the cerebral ischemia-reperfusion, and ozagrel prevented this increase. Additionally, ozagrel also increased the level of 6-keto-PGF1α, a metabolite of prostaglandin I2 (PGI2), in the brain tissue after cerebral ischemia-reperfusion, and the administration of PGI2 improved the reduced spontaneous locomotor activity in the conscious cerebral ischemia-reperfusion mouse model. Our data suggest that ozagrel suppressed the obstruction following cerebral ischemia-reperfusion by preserving the cerebral blood flow via preventing the increase in TXA2 and causing an increase in the PGI2 level.

更新日期：1999-01-01

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