Lactobionic acid has appeared on the commercial scene as a versatile polyhydroxy acid with numerous promising applications in the food, medicine, pharmaceutical, cosmetics and chemical industries. This high value-added bio-product has recently received growing attention as a bioactive compound, providing an excellent chemical platform for the synthesis of novel potentially biocompatible and biodegradable drug delivery vehicles. Recent advances in tissue engineering and nanomedicine have also underlined the increased importance of this organic acid as a key biofunctionalization agent. The growing commercial relevance of lactobionic acid has therefore prompted the development of novel systems for its biotechnological production that are both sustainable and efficient. The present review explores recent advances and studies related to lactobionic acid bio-production, whether through microbial or enzymatic approaches, highlighting the key bioprocessing conditions for enhanced bio-production. Detailed overviews of the current microbial cell factories as well as downstream processing methodologies for lactobionic acid production are also presented. Furthermore, the potential prospects and current applications of this polyhydroxy acid are also discussed, with an emphasis on the role of lactobionic acid as a key platform in the development of novel drugs, biomaterials, nanoparticles and biopolymer systems.

乳酸乳糖酸已作为一种通用的多羟基酸出现在商业舞台上，在食品，医药，制药，化妆品和化学工业中有许多有希望的应用。这种高附加值的生物产品作为一种生物活性化合物，近来受到越来越多的关注，为合成新型具有潜在生物相容性和可生物降解作用的药物递送载体提供了极好的化学平台。组织工程和纳米医学的最新进展也强调了这种有机酸作为关键生物功能化剂的重要性日益提高。因此，乳糖酸的商业重要性与日俱增，促使人们开发出可持续且高效的生物技术生产新系统。本综述探讨了通过微生物或酶促方法与乳糖酸生物生产有关的最新进展和研究，强调了增强生物生产的关键生物加工条件。还介绍了当前微生物细胞工厂的详细概述以及生产乳糖酸的下游加工方法。此外，还讨论了这种多羟基酸的潜在前景和当前应用，重点是乳糖酸作为新型药物，生物材料，纳米颗粒和生物聚合物系统开发中的关键平台的作用。还介绍了当前微生物细胞工厂的详细概述以及生产乳糖酸的下游加工方法。此外，还讨论了这种多羟基酸的潜在前景和当前应用，重点是乳糖酸作为新型药物，生物材料，纳米颗粒和生物聚合物系统开发中的关键平台的作用。还介绍了当前微生物细胞工厂的详细概述以及生产乳糖酸的下游加工方法。此外，还讨论了这种多羟基酸的潜在前景和当前应用，重点是乳糖酸作为新型药物，生物材料，纳米颗粒和生物聚合物系统开发中的关键平台的作用。