This review outlines the recent developments on carboxymethyl chitosan-based bio-medical applications. Carboxymethyl chitosan, a water soluble derivative of chitosan, with enhanced biological and physicochemical properties compared to chitosan, has emerged as a promising candidate for different biomedical applications. Introducing small chemical groups like carboxymethyl to the chitosan structure can drastically increase the solubility of chitosan at neutral and alkaline pH values without affecting their characteristic properties. Due to improved biocompatibility, high moisture retention ability more viscosity and enhanced antimicrobial property of carboxymethyl chitosan than chitosan makes it promising candidate for hydrogels and wound healing applications. The biodegradability and biocompatibility of carboxymethyl chitosan has significant interest with application as biomaterial for tissue engineering. Apart from this, the easy of carboxymethyl chitosan can be easily processed into nanoparticles so it has shown promise for drug delivery, bioimaging, biosensors and gene therapy applications. The contribution of carboxymethyl chitosan to green chemistry in the recent years has also been given in detail. This review will focus on preparative methods and physicochemical and biological properties of carboxymethyl chitosan with particular emphasis on biomedical and pharmaceutical applications of this derivative of chitosan.

中文翻译：

---

羧甲基壳聚糖的生物医学应用。

这篇综述概述了基于羧甲基壳聚糖的生物医学应用的最新发展。羧甲基壳聚糖是壳聚糖的水溶性衍生物，与壳聚糖相比，具有增强的生物学和理化特性，已成为各种生物医学应用的有希望的候选者。在壳聚糖结构中引入小的化学基团（如羧甲基）可以在不影响其特性的情况下，大幅提高壳聚糖在中性和碱性pH值下的溶解度。由于改善了生物相容性，羧甲基壳聚糖比壳聚糖具有更高的保水能力，更高的粘度和增强的抗菌性能，使其成为水凝胶和伤口愈合应用的有希望的候选者。羧甲基壳聚糖作为组织工程生物材料的应用具有极大的兴趣。除此之外，羧甲基壳聚糖的易加工性可以容易地加工成纳米颗粒，因此它显示了在药物输送，生物成像，生物传感器和基因治疗应用中的前景。近年来，也详细介绍了羧甲基壳聚糖对绿色化学的贡献。这篇综述将侧重于羧甲基壳聚糖的制备方法以及理化和生物学性质，特别是对这种壳聚糖衍生物的生物医学和药学应用。羧甲基壳聚糖的易加工性很容易加工成纳米颗粒，因此在药物输送，生物成像，生物传感器和基因治疗应用中显示出了希望。近年来，也详细介绍了羧甲基壳聚糖对绿色化学的贡献。这篇综述将侧重于羧甲基壳聚糖的制备方法以及理化和生物学性质，特别是对这种壳聚糖衍生物的生物医学和药学应用。羧甲基壳聚糖的易加工性很容易加工成纳米颗粒，因此在药物输送，生物成像，生物传感器和基因治疗应用中显示出了希望。近年来，也详细介绍了羧甲基壳聚糖对绿色化学的贡献。这篇综述将侧重于羧甲基壳聚糖的制备方法以及理化和生物学性质，特别是对这种壳聚糖衍生物的生物医学和药学应用。