4-Amino-7-(5'-deoxy-β-D-xylofuranosyl)-5-iodo-pyrrolo[2,3-d]pyrimidine 1, an unusual naturally occurring marine nucleoside isolated from an ascidan, Diplosoma sp., was synthesized from D-xylose in seven steps with 28% overall yield on 10 g scale. The key step was Vorbrüggen glycosylation of 5-iodo-pyrrolo[2,3-d]pyrimidine with 5-deoxy-1,2-O-diacetyl-3-O-benzoyl-D-xylofuranose. Its absolute configuration was confirmed.

中文翻译：

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首次全合成天然存在的碘化 5'-脱氧呋喃糖基海洋核苷。

4-Amino-7-(5'-deoxy-β-D-xylofuranosyl)-5-iodo-pyrrolo[2,3-d]pyrimidine 1，一种不寻常的天然存在的海洋核苷，从海鞘 Diplosoma sp. 中分离出来。由 D-木糖分 7 步合成，10 g 规模的总产率为 28%。关键步骤是 5-碘代吡咯并[2,3-d]嘧啶与 5-deoxy-1,2-O-diacetyl-3-O-benzoyl-D-xylofuranose 的 Vorbrüggen 糖基化。其绝对构型得到确认。