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Recent clinical evidence of the efficacy and safety of thiamphenicol glycinate acetylcysteinate and thiamphenicol glycinate.
Journal of Chemotherapy ( IF 1.9 ) Pub Date : 2002-07-18 , DOI: 10.1179/joc.2002.14.3.279
C Grassi 1 , F De Benedetto
Affiliation  

Thiamphenicol is a broad-spectrum antimicrobial agent active against penicillin-resistant Streptococcus pneumoniae, Staphylococcus aureus VISA strains, most methicillin-resistant isolates and atypical pathogens such as Mycoplasma pneumoniae and Chlamydia pneumoniae). Thiamphenicol is present as glycinate hydrochloride (TG) and glycinate acetylcysteinate (TGA) esters in the parenteral and aerosol dosage form. This multicenter, double-blind, randomized clinical trial aimed to evaluate the efficacy and tolerability of aerosol administration of TGA, compared to TG, in the treatment of acute and/or exacerbated infections of the respiratory tract. Results showed that both treatments ameliorated the symptoms (frequency and severity of cough, difficulty in expectoration) associated with the evaluated pathologies, i.e. tracheobronchitis, acute and exacerbated chronic bronchitis. The investigators rated both treatments Good or Very Good in 90% of patients at the end of treatment, with "Very Good" for patients treated with TGA (37%) compared to 28% of patients treated with TG. Both treatments were well tolerated with fewer than 5% of patients experiencing an adverse event.

中文翻译:

甘氨苯砜,乙酰半胱氨酸和甘氨苯砜的功效和安全性的最新临床证据。

甲砜霉素是一种广谱抗菌剂,对耐青霉素的肺炎链球菌,金黄色葡萄球菌VISA菌株,大多数耐甲氧西林的分离株和非典型病原体(如支原体肺炎和肺炎衣原体)具有活性。噻吩酚以肠胃外和气雾剂形式的甘氨酸盐酸盐(TG)和甘氨酸乙酰半胱氨酸(TGA)酯形式存在。这项多中心,双盲,随机临床试验旨在评估与TG相比TGA气雾剂在治疗急性和/或急性呼吸道感染中的功效和耐受性。结果表明,两种治疗均改善了与所评估的病理相关的症状(咳嗽的频率和严重程度,咳痰困难),即气管支气管炎,急性和加重的慢性支气管炎。研究人员在治疗结束时对90%的患者对两种治疗的评价为“好”或“非常好”,对于TGA治疗的患者(37%)为“非常好”,而TG治疗的患者为28%。两种治疗均耐受良好,少于5%的患者发生不良事件。
更新日期:2019-11-01
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