The insecticidal and phytotoxic activities of destruxins (dtxs) have been well studied. The cyclodepsipeptides, which are dtxs mainly isolated from the fungus Metarhizium anisopliae and other fungi, have been well characterized in vitro and in vivo. A succession of important function, such as antitumoral, antiviral, insecticidal, cytotoxic, immunosuppressant, phytotoxic, and antiproliferative effects have been observed. To date, 39 dtxs derivatives have been identified. Dtxs possess a variety of biological activities, including acting as virulence factors for specific insects, a V-ATPase inhibitor that provides a basis for the development of new drug to against osteoporosis, cancer, or biological control agents, etc. Here, we focus on some of the research progress made on understanding dtxs during the last decade, introduce some of the newly identified dtx members, especially from M. anisopliae, and give an overview of the applications of dtxs. Using the dtxs to learn about and moderate biological events has advanced significantly during the past year. We believe that several ongoing dtx application fields may benefit from the reviewed information herein.

已经对蠕虫毒素（dtxs）的杀虫和植物毒性活性进行了充分的研究。环二肽是主要从真菌Anterhizium anisopliae和其他真菌中分离的dtx，在体外和体内均已得到很好的鉴定。已经观察到一系列重要功能，例如抗肿瘤，抗病毒，杀虫，细胞毒性，免疫抑制剂，植物毒性和抗增殖作用。迄今为止，已经鉴定出39种dtxs衍生物。Dtxs具有多种生物活性，包括作为毒力因子对特定昆虫，一个V-ATP酶抑制剂，其提供了一种用于新药的发展，以对抗骨质疏松症，癌症，或生物控制剂，基础等。在这里，我们重点介绍过去十年中在了解dtx方面取得的一些研究进展，介绍一些新近确定的dtx成员，尤其是来自M的成员。菌，并给予dtxs的应用程序的概述。在过去的一年中，使用dtx来了解和温和的生物学事件有了很大的进步。我们认为，几个进行中的dtx应用领域可能会从本文中回顾的信息中受益。