This paper presents a reevaluation of the synthesis and properties of Fmoc-His(3-Bum)-OH regarding its application in SPPS with minimal racemization of histidine residues during coupling and esterification reactions. By-product formation during the deprotection of the test peptides could be significantly reduced by scavenging the concomitantly formed HCHO, e.g. with methoxyamine.

中文翻译：

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Fmoc-His（3-Bum）-OH的合成与应用。

本文介绍了Fmoc-His（3-Bum）-OH在SPPS中的应用及其在偶联和酯化反应过程中组氨酸残基的外消旋最小化方面的合成和性能。通过清除伴随形成的HCHO，例如用甲氧基胺，可以大大减少测试肽脱保护过程中副产物的形成。