Two new neoclerodane diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), scutebata B (4), scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines LoVo, SMMC-7721, HCT-116, and MCF-7 were evaluated, compound 1 and 2 showed weak cytotoxic activities against HCT-116 colon cancer cell lines with IC50 value of 44.3, 32.3 μM, respectively, while compound 3 and 4 exhibited moderate cytotoxic activities against four tested human cancer cell lines with IC50 values of 5.31～28.5 μM.

中文翻译：

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来自半枝S的新环戊烷二萜具有细胞毒活性。

从整体中分离出两个新的新环戊烷二萜类化合物，barbatin F（1），barbatin G（2）以及四种已知化合物，scutebata A（3），scutebata B（4），scutebata C（5）和scutebata P（6）。黄cutD.Don的植物。在光谱研究的基础上阐明了它们的结构。评估了所选化合物对癌细胞LoVo，SMMC-7721，HCT-116和MCF-7的体外细胞毒性，化合物1和2对HCT-116结肠癌细胞系的细胞毒性较弱，IC50值分别为44.3、32.3 μM，而化合物3和4对四种受试人类癌细胞系表现出中等的细胞毒活性，IC50值为5.31〜28.5μM。