AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard (SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome (ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM, chlorine gas and radiation exposure studies.

中文翻译：

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SOD模拟剂AEOL-10150（一种有效的广谱抗氧化剂）的改进。

AEOL-10150是一种广谱金属卟啉超氧化物酶歧化酶（SOD）模仿物，专门设计用于中和活性氧和氮物质。研究表明，AEOL-10150是针对国家安全威胁的有效医学对策，其中包括足以引起急性放射综合症（ARS）的放射/核事故之后的硫芥子气（SM），神经毒剂暴露和放射性肺炎。AEOL-10150在动物安全性研究中表现良好，并且在患者中进行的两项完整的1期安全性研究表明，该药物安全且耐受性良好，表明AEOL-10150具有作为新型催化抗氧化剂的潜力。在本文中，我们回顾了AEOL-10150在临床前药效学研究方面的改进，尤其是在抗SM，氯气和辐射暴露研究方面。