OBJECTIVE To evaluate the protective effect of catalpol against diabetic nephropathy in db/db mouse. METHODS 8 week old C57BLKS/J db/db mice (type 2 diabetic mouse model) were divided into three groups to feed for 16 weeks on chow diet with or without catalpol supplementation. Their food intake, water consumption, body weight, and fasting glucose levels were recorded every 4 weeks. At the end of study, urine and blood samples were examined for several metabolic variables, and kidneys were harvested for structural characterization and microarray analysis. RESULTS Catalpol efficiently lowers the fasting glucose and the 24 h urinary albumin excretion rate. Catalpol significantly lowers serum triglycerides, increases high-density lipoproteins, and improves serum creatinine and urea nitrogen. Catalpol-fed mice preserve their kidney structure and renal function better than chow fed db/db mice. Microarray data indicates that lipid metabolism is a potential target of catalpol in exerting protective effect. CONCLUSION Catalpol has a renal protective effect in diabetic db/db mice.

中文翻译：

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Catalpol通过改善糖尿病db / db小鼠的脂质代谢来减轻肾脏损害。

目的评价梓醇对db / db小鼠糖尿病肾病的保护作用。方法将8周大的C57BLKS / J db / db小鼠（2型糖尿病小鼠模型）分为三组，分别在补充或不补充catalpol的基础上进食16周。每4周记录一次他们的食物摄入量，水消耗量，体重和空腹血糖水平。在研究结束时，检查尿液和血液样本中的几个代谢变量，并收集肾脏进行结构表征和微阵列分析。结果Catalpol可有效降低空腹血糖和24 h尿白蛋白排泄率。Catalpol可显着降低血清甘油三酸酯，增加高密度脂蛋白并改善血清肌酐和尿素氮。由Catalpol喂养的小鼠比以食物喂养的db / db小鼠更好地保留了其肾脏结构和肾功能。微阵列数据表明脂质代谢是Catalpol发挥保护作用的潜在目标。结论Catalpol对糖尿病db / db小鼠具有肾脏保护作用。