BACKGROUND Whether or not the period of fetal lung maturity differs between twin and singleton pregnancies has not been clarified. We examined whether or not fetal lung maturity and fetal lung absorption are achieved earlier in twin fetuses than in singleton fetuses. METHODS We registered 454 singleton pregnancies and 398 twin pregnancies with no congenital abnormalities affecting the respiratory function or neonatal deaths. All patients were delivered by Caesarean section without labor between 24 and 38 gestational weeks. The amniotic fluid samples were analyzed immediately without centrifugation. A multiple logistic regression analysis was performed to explore the relationship between twin pregnancy and neonatal respiratory distress syndrome and transient tachypnea of the newborn (RDS/TTN). RESULTS The rate of RDS/TTN in infants was significantly higher and the lamellar body counts (LBCs) significantly lower in singleton pregnancies than that in twin pregnancies (P < .001). According to a multivariate logistic regression analysis, twin pregnancy (odds ratio, 0.34; 95% confidence interval, 0.22-0.55) was a significant preventive factor for neonatal RDS/TTN. CONCLUSIONS We showed that twin fetuses experience more rapid lung maturation and lung fluid absorption than singleton fetuses, as confirmed by the higher LBC values in twin fetuses.

中文翻译：

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与单胎妊娠相比，双胎妊娠新生儿的新生儿呼吸窘迫综合征/短暂性呼吸急促的比率和羊膜状体计数。

背景技术尚不清楚双胎和单胎妊娠的胎儿肺成熟期是否不同。我们检查了双胎胎儿是否比单胎胎儿更早实现了胎肺成熟和胎肺吸收。方法我们登记了454例单胎妊娠和398例双胎妊娠，没有先天性异常影响呼吸功能或新生儿死亡。在妊娠24至38周之间，所有患者均经剖腹产分娩。立即对羊水样品进行分析，无需离心。进行了多元逻辑回归分析，以探讨双胞胎妊娠与新生儿呼吸窘迫综合征和新生儿短暂性呼吸急促之间的关系（RDS / TTN）。结果与单胎妊娠相比，单胎妊娠的婴儿RDS / TTN率显着较高，而层状体计数（LBC）则显着降低（P <.001）。根据多因素logistic回归分析，双胎妊娠（几率0.34； 95％置信区间0.22-0.55）是新生儿RDS / TTN的重要预防因素。结论我们证明，双胎胎儿比单胎胎儿具有更快的肺成熟和肺液吸收能力，这一点已被双胎胎儿较高的LBC值所证实。55）是新生儿RDS / TTN的重要预防因素。结论我们证明，双胎胎儿比单胎胎儿具有更快的肺成熟和肺液吸收能力，这一点已被双胎胎儿较高的LBC值所证实。55）是新生儿RDS / TTN的重要预防因素。结论我们证明，双胎胎儿比单胎胎儿具有更快的肺成熟和肺液吸收能力，这一点已被双胎胎儿较高的LBC值所证实。