全氟辛基溴化物纳米颗粒，用于超声成像和药物递送。,International Journal of Nanomedicine

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全氟辛基溴化物纳米颗粒，用于超声成像和药物递送。
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2018-06-07 , DOI: 10.2147/ijn.s164905
Xiao Li ₁ , Zhongguo Sui ₁ , Xin Li ₁ , Wen Xu ₁ , Qie Guo ₁ , Jialin Sun ₁ , Fanbo Jing ₁

Affiliation

全氟辛基溴化物纳米颗粒（PFOB NPs）是一类多功能纳米技术，已针对各种医学应用进行了研究。商业超声造影剂（UCA）受以下限制：由于其微米尺寸，体内半衰期短，背景信号高以及血管循环分布受限。PFOB NP是新的潜在UCA，可在循环系统中长期存在，具有相对稳定的回声响应，而不会增加背景信号，并且比商业UCA具有更低的声衰减。此外，PFOB NP还可以用作药物输送载体，其中药物溶解在外部脂质或聚合物层中，以便随后在定点治疗中输送到目标部位。使用PFOB NP作为载体具有潜在的优势，可以选择性地将有效载荷传送到目标位置，同时使用超声（US）成像改善该位置的可视化。不幸的是，由于US反射强度低，PFOB NP在超声检查领域的应用受到了限制。许多研究人员已经意识到PFOB NPs作为UCA的潜在用途，因此开发了在超声检查中应用PFOB NPs的替代方法。在本文中，我们回顾了使用PFOB NP增强体内US成像的最新方法。此外，本文强调了PFOB NPs作为有希望的药物输送载体在癌症和动脉粥样硬化治疗中的应用，因为PFOB NPs可以有效地转运各种药物有效载荷用于各种应用。

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Perfluorooctylbromide nanoparticles for ultrasound imaging and drug delivery.

Perfluorooctylbromide nanoparticles (PFOB NPs) are a type of multifunctional nanotechnology that has been studied for various medical applications. Commercial ultrasound contrast agents (UCAs) suffer from the following limitations: short half-lives in vivo, high background signal and restricted distribution in the vascular circulation due to their micrometer dimensions. PFOB NPs are new potential UCAs that persist for long periods in the circulatory system, possess a relatively stable echogenic response without increasing the background signal and exhibit lower acoustic attenuation than commercial UCAs. Furthermore, PFOB NPs may also serve as drug delivery vehicles in which drugs are dissolved in the outer lipid or polymer layer for subsequent delivery to target sites in site-targeted therapy. The use of PFOB NPs as carriers has the potential advantage of selectively delivering payloads to the target site while improving visualization of the site using ultrasound (US) imaging. Unfortunately, the application of PFOB NPs to the field of ultrasonography has been limited because of the low intensity of US reflection. Numerous researchers have realized the potential use of PFOB NPs as UCAs and thus have developed alternative approaches to apply PFOB NPs in ultrasonography. In this article, we review the latest approaches for using PFOB NPs to enhance US imaging in vivo. In addition, this article emphasizes the application of PFOB NPs as promising drug delivery carriers for cancer and atherosclerosis treatments, as PFOB NPs can transport different drug payloads for various applications with good efficacy. We also note the challenges and future study directions for the application of PFOB NPs as both a delivery system for therapeutic agents and a diagnostic agent for ultrasonography.

更新日期：2019-11-01

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