人参皂苷 Rb1、Rg1 和 Rg3 的分子信号及其作用方式,Journal of Ginseng Research

当前位置： X-MOL 学术 › J. Ginseng Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

人参皂苷 Rb1、Rg1 和 Rg3 的分子信号及其作用方式
Journal of Ginseng Research ( IF 6.8 ) Pub Date : 2018-04-01 , DOI: 10.1016/j.jgr.2017.01.008
Padmanaban Mohanan ₁ , Sathiyamoorthy Subramaniyam ₂ , Ramya Mathiyalagan ₁ , Deok-Chun Yang _{1,

2}

Affiliation

人参因其三萜皂苷，即人参皂苷，自古以来就作为适应原广受欢迎。这些三萜皂苷是独一无二的，根据它们的糖基化模式分为原人参三醇和原人参二醇皂苷。它们在人类中发挥着许多保护作用，并且随着各个团体继续在分子水平上研究它们在各种疾病中的功效，它们正处于紧张的研究之中。人参皂苷 Rb1 和 Rg1 是人参根中含量最丰富的人参皂苷，它们赋予植物的药理特性，而人参皂苷 Rg3 大量存在于以抗癌作用而闻名的高丽红参制剂中。这些人参皂苷在调节不同组织中的各种信号级联和网络方面具有独特的作用模式。它们的作用取决于细胞的生物利用度和生理状态。大多数情况下，它们通过刺激磷酸肌醇-4,5-二磷酸 3-激酶/蛋白激酶 B 途径、caspase-3/caspase-9 介导的凋亡途径、单磷酸腺苷活化蛋白激酶和核因子 kappa-轻链来放大反应- 增强激活的 B 细胞信号。此外，它们触发受体，如雌激素受体、糖皮质激素受体和 N-甲基-d-天冬氨酸受体。这篇综述批判性地评估了人参皂苷 Rb1、Rg1 和 Rg3 在各种组织中减弱的信号通路，重点是癌症、糖尿病、心血管疾病和神经退行性疾病。5-二磷酸 3-激酶/蛋白激酶 B 通路、caspase-3/caspase-9 介导的凋亡通路、单磷酸腺苷活化蛋白激酶和活化 B 细胞信号传导的核因子 kappa-轻链增强剂。此外，它们触发受体，如雌激素受体、糖皮质激素受体和 N-甲基-d-天冬氨酸受体。这篇综述批判性地评估了人参皂苷 Rb1、Rg1 和 Rg3 在各种组织中减弱的信号通路，重点是癌症、糖尿病、心血管疾病和神经退行性疾病。5-二磷酸 3-激酶/蛋白激酶 B 通路、caspase-3/caspase-9 介导的凋亡通路、单磷酸腺苷活化蛋白激酶和活化 B 细胞信号传导的核因子 kappa-轻链增强剂。此外，它们触发受体，如雌激素受体、糖皮质激素受体和 N-甲基-d-天冬氨酸受体。这篇综述批判性地评估了人参皂苷 Rb1、Rg1 和 Rg3 在各种组织中减弱的信号通路，重点是癌症、糖尿病、心血管疾病和神经退行性疾病。糖皮质激素受体和 N-甲基-d-天冬氨酸受体。这篇综述批判性地评估了人参皂苷 Rb1、Rg1 和 Rg3 在各种组织中减弱的信号通路，重点是癌症、糖尿病、心血管疾病和神经退行性疾病。糖皮质激素受体和 N-甲基-d-天冬氨酸受体。这篇综述批判性地评估了人参皂苷 Rb1、Rg1 和 Rg3 在各种组织中减弱的信号通路，重点是癌症、糖尿病、心血管疾病和神经退行性疾病。

"点击查看英文标题和摘要"

Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions

Ginseng has gained its popularity as an adaptogen since ancient days because of its triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and classified as protopanaxatriol and protopanaxadiol saponins based on their glycosylation patterns. They play many protective roles in humans and are under intense research as various groups continue to study their efficacy at the molecular level in various disorders. Ginsenosides Rb1 and Rg1 are the most abundant ginsenosides present in ginseng roots, and they confer the pharmacological properties of the plant, whereas ginsenoside Rg3 is abundantly present in Korean Red Ginseng preparation, which is highly known for its anticancer effects. These ginsenosides have a unique mode of action in modulating various signaling cascades and networks in different tissues. Their effect depends on the bioavailability and the physiological status of the cell. Mostly they amplify the response by stimulating phosphotidylinositol-4,5-bisphosphate 3-kinase/protein kinase B pathway, caspase-3/caspase-9-mediated apoptotic pathway, adenosine monophosphate-activated protein kinase, and nuclear factor kappa-light-chain-enhancer of activated B cells signaling. Furthermore, they trigger receptors such as estrogen receptor, glucocorticoid receptor, and N-methyl-d-aspartate receptor. This review critically evaluates the signaling pathways attenuated by ginsenosides Rb1, Rg1, and Rg3 in various tissues with emphasis on cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders.

更新日期：2018-04-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南