While prognosis for breast cancer in women has improved, adverse side effects of treatments may negatively affect body composition and bone mineral density (BMD). This study assessed body composition and BMD changes in breast cancer survivors (BCS) (n = 10, 57.9 ± 5.7 years) and age-matched women (non-cancer, n = 10, 56.5 ± 4.3 years) over a 12- to 15-month period via dual-energy X-ray absorptiometry. No differences were observed between groups at baseline except forearm BMD values were lower in BCS (BCS: 0.462 ± 0.070 g/cm2 ; Control: 0.539 ± 0.052 g/cm2 , p = .012). Body fat increased in both groups compared to baseline (BCS: 38.3-39.6 kg, p = .013; Control: 38.2-39.5 kg, p = .023) at the follow-up. Significant decreases in BMD at the lumbar spine, femoral neck, total femur and ulna were observed in both groups. Breast cancer survivors had a greater decrease in left femoral neck BMD. While BCS demonstrated lower baseline forearm BMD values and a greater decrease in left femoral neck BMD, both groups showed an increase in body fat and decrease in forearm BMD. These findings support the implementation of interventions to improve body composition and BMD in both BCS and women without cancer.

中文翻译：

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乳腺癌幸存者和非癌症对照者的身体成分和骨矿物质密度：12至15个月的随访。

尽管女性乳腺癌的预后得到改善，但治疗的不良副作用可能会对身体成分和骨矿物质密度（BMD）产生负面影响。这项研究评估了12至15岁的乳腺癌幸存者（BCS）（n = 10，57.9±5.7岁）和年龄相匹配的女性（非癌症，n = 10，56.5±4.3岁）的身体成分和BMD变化。双能X射线骨密度仪测量一个月的时间。基线时各组之间没有观察到差异，除了前臂BCS的BMD值较低（BCS：0.462±0.070 g / cm2；对照：0.539±0.052 g / cm2，p = 0.012）。与基线相比，两组的身体脂肪均增加（BCS：38.3-39.6 kg，p = .013；对照组：38.2-39.5 kg，p = .023）。两组均观察到腰椎，股骨颈，总股骨和尺骨骨密度明显下降。乳腺癌幸存者的左股骨颈BMD下降更大。虽然BCS表现出较低的前臂基线BMD值和左股骨颈BMD较大的下降，但两组均显示出身体脂肪增加和前臂BMD下降。这些发现支持在BCS和没有癌症的妇女中实施旨在改善身体成分和BMD的干预措施。