BACKGROUND We evaluated the relationships between corneal biomechanical properties and structural parameters in patients with newly diagnosed, untreated normal-tension glaucoma (NTG). METHODS All subjects were evaluated using an Ocular Response Analyzer (ORA) measuring corneal hysteresis (CH) and the corneal resistance factor (CRF). Central corneal thickness (CCT), Goldmann applanation tonometric (GAT) data, axial length, and the spherical equivalent (SE), were also measured. Confocal scanning laser ophthalmoscopy was performed with the aid of a Heidelberg retina tomograph (HRT III). We sought correlations between HRT parameters and different variables including CCT, CH, and the CRF. Multiple linear regression analysis was performed to identify significant associations between corneal biomechanical properties and optic nerve head parameters. RESULTS We enrolled 95 eyes of 95 NTG patients and 93 eyes of 93 normal subjects. CH and the CRF were significantly lower in more advanced glaucomatous eyes (P = 0.001, P = 0.008, respectively). The rim area, rim volume, linear cup-to-disc ratio (LCDR), and mean retinal nerve fiber layer (RNFL) thickness were significantly worse in more advanced glaucomatous eyes (P < 0.001, P < 0.001, P < 0.001, and P = 0.001). CH was directly associated with rim area, rim volume, and mean RNFL thickness (P = 0.012, P = 0.028, and P = 0.043) and inversely associated with LCDR (P = 0.015), after adjusting for age, axial length, CCT, disc area, GAT data, and SE. However, in normal subjects, there were no significant associations between corneal biomechanical properties and HRT parameters. CONCLUSIONS A lower CH is significantly associated with a smaller rim area and volume, a thinner RNFL, and a larger LCDR, independent of disc size, corneal thickness, intraocular pressure, and age.

中文翻译：

---

正常血压青光眼患者角膜生物力学特性与结构生物标志物之间的关系：一项回顾性研究。

背景我们评估了新诊断，未经治疗的正常血压青光眼（NTG）患者的角膜生物力学特性与结构参数之间的关系。方法使用眼反应分析仪（ORA）测量角膜滞后（CH）和角膜抵抗因子（CRF）评估所有受试者。还测量了中央角膜厚度（CCT），Goldmann压平眼压（GAT）数据，轴向长度和球当量（SE）。借助海德堡视网膜断层扫描仪（HRT III）进行共聚焦扫描激光检眼镜。我们寻求HRT参数和不同变量（包括CCT，CH和CRF）之间的相关性。进行了多元线性回归分析，以鉴定角膜生物力学特性与视神经头参数之间的显着关联。结果我们纳入了95例NTG患者的95眼和93例正常受试者的93眼。在较高级的青光眼中，CH和CRF明显降低（分别为P = 0.001，P = 0.008）。在更高级的青光眼眼中，边缘区域，边缘体积，线性杯碟比（LCDR）和平均视网膜神经纤维层（RNFL）厚度明显较差（P <0.001，P <0.001，P <0.001和P = 0.001）。在调整了年龄，轴向长度，CCT后，CH与轮辋面积，轮辋体积和平均RNFL厚度直接相关（P = 0.012，P = 0.028和P = 0.043），与LCDR呈负相关（P = 0.015）。光盘区域，GAT数据和SE。然而，在正常受试者中，角膜生物力学特性与HRT参数之间没有显着关联。