BACKGROUND Compelling evidence suggests that excessive alcohol consumption increases the risk of atrial fibrillation (AF), but the effect of light-moderate alcohol consumption is less certain. We investigated the association between alcohol consumption within recommended limits and AF risk in a light-drinking population. METHODS AND RESULTS Among 47 002 participants with information on alcohol consumption in a population-based cohort study in Norway, conducted from October 2006 to June 2008, 1697 validated AF diagnoses were registered during the 8 years of follow-up. We used Cox proportional hazard models with fractional polynomials to analyze the association between alcohol intake and AF. Population attributable risk for drinking within the recommended limit (ie, at most 1 drink per day for women and 2 drinks per day for men without risky drinking) compared with nondrinking was also calculated. The average alcohol intake was 3.8±4.8 g/d. The adjusted hazard ratio for AF was 1.38 (95% confidence interval, 1.06-1.80) when we compared participants consuming >7 drinks per week with abstainers. When we modeled the quantity of alcohol intake as a continuous variable, the risk increased in a curvilinear manner. It was higher with heavier alcohol intake, but there was virtually no association at <1 drink per day for women and <2 drinks per day for men in the absence of risky drinking. The population attributable risk among nonrisky drinkers was 0.07% (95% confidence interval, -0.01% to 0.13%). CONCLUSIONS Although alcohol consumption was associated with a curvilinearly increasing risk of AF in general, the attributable risk of alcohol consumption within recommended limits among participants without binge or problem drinking was negligible in this population.

中文翻译：

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适量饮酒会增加心房颤动的风险吗？挪威 HUNT（北特伦德拉格健康）研究。


背景令人信服的证据表明，过量饮酒会增加心房颤动（AF）的风险，但轻度至中度饮酒的影响不太确定。我们调查了少量饮酒人群中建议限度内的饮酒量与房颤风险之间的关联。方法和结果 2006 年 10 月至 2008 年 6 月在挪威进行的一项基于人群的队列研究中，在 47 002 名有饮酒信息的参与者中，在 8 年的随访期间登记了 1697 例经过验证的 AF 诊断。我们使用带有分数多项式的 Cox 比例风险模型来分析酒精摄入量与 AF 之间的关联。还计算了与不饮酒相比，在建议限度内饮酒（即女性每天最多 1 杯，男性每天最多 2 杯，无危险饮酒）的人群归因风险。平均酒精摄入量为3.8±4.8克/天。当我们将每周饮用 >7 饮料的参与者与戒酒者进行比较时，调整后的 AF 风险比为 1.38（95% 置信区间，1.06-1.80）。当我们将酒精摄入量建模为连续变量时，风险以曲线方式增加。酒精摄入量越多则越高，但在没有危险饮酒的情况下，女性每天饮酒 <1 和男性每天饮酒 <2 几乎没有关联。无风险饮酒者的人群归因风险为 0.07%（95% 置信区间，-0.01% 至 0.13%）。结论 虽然饮酒总体上与房颤风险曲线增加相关，但在该人群中，没有暴饮暴食或饮酒问题的参与者中，在建议限度内饮酒的归因风险可以忽略不计。