Skeletal muscle dysfunction (i.e., myopathy) is common in patients with alcohol use disorder. However, few clinical studies have elucidated the significance, mechanisms, and therapeutic options of alcohol-related myopathy. Preclinical studies indicate that alcohol adversely affects both anabolic and catabolic pathways of muscle-mass maintenance and that an increased proinflammatory and oxidative milieu in the skeletal muscle is the primary contributing factor leading to alcohol-related skeletal muscle dysfunction. Decreased regenerative capacity of muscle progenitor cells is emerging as an additional mechanism that contributes to alcohol-induced loss in muscle mass and impairment in muscle growth. This review details the epidemiology of alcoholic myopathy, potential contributing pathophysiologic mechanisms, and emerging literature on novel therapeutic options.

中文翻译：

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酒精性肌病：病理生理机制和临床意义。

酒精使用障碍患者常见骨骼肌功能障碍（即肌病）。然而，很少有临床研究阐明酒精相关性肌病的重要性，机制和治疗选择。临床前研究表明，酒精对肌肉质量维持的合成代谢和分解代谢途径均产生不利影响，骨骼肌中促炎和氧化环境的增加是导致酒精相关骨骼肌功能障碍的主要因素。肌肉祖细胞再生能力的下降是一种新的机制，它是酒精引起的肌肉质量下降和肌肉生长受损的另一种机制。这篇评论详细介绍了酒精性肌病的流行病学，潜在的病理生理机制，