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Two new 2-(2-Hydroxy-2-phenylethyl)chromens from agarwood originating from Aquilaria crassna.
Journal of Asian Natural Products Research ( IF 1.3 ) Pub Date : 2017-10-06 , DOI: 10.1080/10286020.2017.1379998
Hong-Ni Wang 1 , Wen-Li Mei 1 , Wen-Hua Dong 1 , Fan-Dong Kong 1 , Wei Li 1 , Jing-Zhe Yuan 1 , Hao-Fu Dai 1
Affiliation  

Two new 2-(2-hydroxy-2-phenylethyl)chromones (1‒2), along with three known 2-(2-phenylethyl)chromones (3‒5), were isolated from the agarwood originating from Aquilaria crassna Pierre ex Lecomte. Their structures were determined by the spectroscopic methods including 1D and 2D NMR analysis and comparison with reported data in the literature. All the compounds were isolated from agarwood of A. crassna for the first time. Compounds 1 and 2 exhibited inhibitory activity against acetylcholinesterase (AChE) with 17.4 ± 0.6 and 15.8 ± 0.7%, respectively, at a concentration of 50 μg/ml. Besides, Compound 3 expressed antibacterial activities against Ralstonia solanacearum with diameter of the inhibition zone of 6.80 ± 0.08 mm at a concentration of 10 mg/ml.



中文翻译:

来自沉香木的沉香木中的两个新的2-(2-羟基-2-苯乙基)色料。

两个新的2-(2-羟基-2-苯乙基)色酮(1-2)中,用三个已知2-(2-苯乙基)色酮(沿3-5)中,从从沉香始发分离沉香惠安皮尔前孔特通过包括1D和2D NMR分析在内的光谱方法确定其结构,并与文献中报道的数据进行比较。所有化合物购自的沉香分离A.惠安首次化合物12在50μg/ ml的浓度下分别具有17.4±0.6%和15.8±0.7%的抗乙酰胆碱酯酶(AChE)抑制活性。此外,化合物3在10 mg / ml的浓度下,其对青枯雷尔氏菌的抑菌直径为6.80±0.08 mm。

更新日期:2017-10-06
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